【摘要】 非编码RNA(non-coding RNA,ncRNA)指不具备编码蛋白质潜力的RNA，根据不同的生物学特性主要分为微RNA(microRNA,miRNA)、长链非编码RNA(long non-coding RNA,lncRNA)及环状RNA(circular RNA,circRNA)，它们在多种生命活动中发挥调节作用。妊娠是一个非常复杂的生理过程，成功的妊娠需要多个步骤协调推进，胚胎着床作为其中的关键步骤，其过程受到多种因素的调控，调控范围包括胚胎发育、子宫内膜状态的改变及母体-胚胎“通信”的进行，多种调控机制的存在保障了胚胎的定位、黏附、侵入，最终顺利着床。MiRNA、lncRNA及circRNA是目前研究较为广泛的ncRNA，通过靶向调节多个细胞因子、基因的表达在胚胎着床的生理和病理过程中发挥重要的调控作用。随着分子生物学技术的发展，有望从分子角度为临床上预测及改善妊娠结局提供思路和方法。更多还原

【Abstract】 Non-coding RNA(ncRNA) refers to RNA that lack the ability to encode protein. Based on their distinct biological characteristics, ncRNA are mainly classified into microRNA(miRNA), long non-coding RNA(lncRNA), and circular RNA(circRNA). NcRNA plays a crucial regulatory role in various biological processes. Pregnancy is a highly intricate physiological process that requires successful completion of multiple steps. Embryo implantation, as a key event of pregnancy, which is regulated by numerous factors, including embryo development, endometrial changes, and the maternal-embryo crosstalk. A diverse array of regulatory mechanisms ensures the accomplishment of embryo localization, adhesion, invasion, and ultimately successful implantation. MiRNA, lncRNA, and circRNA are extensively studied ncRNA molecules at present, which play an important role in the physiological and pathological processes associated with embryo implantation through targeting and regulating the expression of multiple cytokine and genes. With advancements in molecular biology technology, it is anticipated that ncRNA will contribute to the prediction and enhancement of clinical pregnancy outcomes from a molecular perspective.更多还原