【摘要】 目的 分析青年偏头痛患者行卵圆孔未闭（PFO）封堵术后的临床疗效。方法 采用回顾性分析研究，选取2021-01—2022-01于商丘市第一人民医院行PFO封堵术的126例青年偏头痛患者，通过与PFO封堵术前对比，随访观察术后3个月、6个月、12个月的临床疗效指标变化，包括偏头痛发作的频率和持续时间、头痛冲击试验（HIT-6）评分，以及视觉模拟量表（VAS）评分等，对比不同级别PFO患者介入封堵术后的缓解程度。结果 PFO闭合后的随访显示，术后偏头痛的平均每月发作频率、持续时间、HIT-6评分及VAS评分均显著降低（P<0.001）。在3个月的随访中，54例（42.9%）患者的头痛指数降低>60%;12个月随访期间，40例（31.7%）患者偏头痛完全缓解，100例（79.3%）患者的头痛指数降低>60%。结论 封堵术可使大部分合并PFO的青年偏头痛患者头痛症状和生活质量得到一定程度的改善，具有一定的临床指导意义。更多还原

【Abstract】 Objective To analyze the clinical efficacy of young migraine patients after patent foramen ovale(PFO) occlusion.Methods Using retrospective analysis method,126 young migraine patients who received PFO occlusion in the First People’s Hospital of Shangqiu from January 2021 to January 2022 were selected to observe and compare the difference in the degree of remission of patients with different levels of PFO after interventionic occlusion.The clinical efficacy indicators were observed and compared with those before PFO occlusion at 3,6,and 12 months after surgery,including frequency and duration of migraine attacks,headache impact test(HIT-6) score,and visual analog scale(VAS) score.Results The follow-up analysis result after PFO closure showed a significant reduction in mean monthly attack frequency,duration,HIT-6 score,and VAS score after the procedure,P<0.001.The headache index of 54 patients(42.9%) decreased by more than 60% after 3 months of treatment.After 12 months,40 patients(31.7%) had complete migraine remission,and 100 patients(79.3%) had a reduction of more than 60% in the headache index.Conclusion The occlusion can improve headache symptoms and quality of life to some extent in most young migraine patients with combined PFO,which is of great clinical guideline significance.更多还原