【摘要】 国内外研究对于穿支动脉疾病（PAD）型脑梗死易出现早期神经功能恶化（END）的机制和危险因素已有一定的结论，但目前对于END的确切病因、病理机制及预测指标尚未完全阐明，仍有不同观点，因此缺乏有效防治措施，耽误最佳时机，导致患者预后不良，满意率低。近期大量研究显示PAD型脑梗死发生END可能与以下临床、检验、影像学等因素有关，有望成为更好的预测指标，未来可能突破PAD型脑梗死治疗的瓶颈，本文就END的发生机制及相关危险因素进行综述。更多还原

【Abstract】 Domestic and foreign studies have reached certain conclusions about the mechanism and risk factors of early neurological deterioration(END) in patients with perforating artery disease(PAD) type cerebral infarction.However,at present,the exact etiology,pathogenesis,and predictive indicators of END have not been fully elucidated,and there are still different views.Therefore,effective prevention and treatment measures are lacking,which delays the best opportunity and leads to poor prognosis of patients,with low satisfaction rate.Recently,a large number of studies have shown that the occurrence of END in patients with PAD type cerebral infarction may be related to the following clinical,laboratory,imaging,and other factors,which are expected to become better predictive indicators.In the future,it may break through the bottleneck in the treatment of PAD type cerebral infarction.This article reviews the pathogenesis and related risk factors of END.更多还原