【摘要】 目的：基于网络药理学方法探究芍药甘草汤治疗葡萄膜炎的效应机制。方法：从我国研发的中药系统药理学数据库与分析平台（TCMSP），筛选得到芍药甘草汤的主要成分及作用靶点，并通过GeneCards、OMIM、DisGeNET、DrugBank数据库获取葡萄膜炎相关的疾病靶点，进而筛选出相同的靶点作为“药物—疾病”交集靶点。利用STRING数据平台和Cytoscape进行PPI分析与网络构建。在DAVID进行富集分析。结果：获得芍药甘草汤成分93个，中药相关靶点214个，疾病靶点1 463个，交集靶点93个。芍药甘草汤治疗葡萄膜炎的重要有效成分有槲皮素、山奈酚、β-谷甾醇、柚皮素、芒柄花素等，主要靶点为AKT1、TNF、IL6、STAT3、PTGS2，通过IL-17信号通路、TNF信号通路、Toll样受体信号通路、Th17细胞分化、弓形虫病等通路发挥作用。结论：芍药甘草汤治疗葡萄膜炎具备多活性成分、多靶点、多渠道的调节免疫、抑制炎症反应的优势，为其临床应用提供了一定的理论依据。更多还原

【Abstract】 Objective:To investigate the mechanism of effect of peony and licorice soup in the treatment of uveitis based on a network pharmacological approach.Methods:The main components and targets of Paeonia lactiflora and Glycyrrhiza glabra soup were screened from the Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform(TCMSP) developed in China, and the disease targets related to uveitis were obtained from GeneCards, OMIM, DisGeNET and DrugBank databases, and then the same targets were screened as “drug-disease” intersection targets. STRING data platform and Cytoscape were used for PPI analysis and network construction. Enrichment analysis was performed at DAVID.Results:There were 93 components of peony and licorice soup, 214 herbal related targets, 1 463 disease targets and 93 intersecting targets. The important active ingredients of Paeonia lactiflora licorice soup for the treatment of uveitis are quercetin, kaempferol, β-sitosterol, naringenin, and mangosteen,etc. The main targets were AKT1, TNF, IL6, STAT3, and PTGS2, which acted through IL-17 signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Th17 cell differentiation, and toxoplasmosis.Conclusion:Paeonia lactiflora and licorice soup for the treatment of uveitis possesses the advantages of multiple active ingredients, multiple targets, and multiple channels for regulating immunity and suppressing inflammatory responses, which provides a certain theoretical basis for its clinical application.更多还原