【摘要】 目的：总结自贡市第一人民医院2020年第4季度抗菌药物细菌耐药性情况并进行深入分析，提出促进抗菌药物合理使用的对策和建议，为临床合理使用抗菌药物提供指导和参考。方法：用Whonet 5.6软件对医院2020年第4季度抗菌药物药敏试验数据进行统计分析，同时依据《抗菌药物临床应用指导原则》及《抗菌药物临床应用管理办法》，对细菌耐药性超过30%的抗菌药物品种做出预警提示，对细菌敏感性高的抗菌药物则筛选出来推荐临床优先选用。结果：对金黄色葡萄球菌：青霉素耐药率超75%，应避免使用；左氧氟沙星、环丙沙星、苯唑西林敏感性高，可优先选用。对肺炎链球菌：红霉素耐药率超过75%，应避免选用；左氧氟沙星、阿莫西林、头孢曲松、头孢噻肟敏感性高，可优先选用。对大肠杆菌：氨苄西林耐药率超过75%，应避免选用；阿米卡星、哌拉西林/他唑巴坦敏感性分别为98.40%和97.6%，可优先选用。对肺炎克雷伯菌：本院常用抗菌药物细菌耐药率较低；哌拉西林/他唑巴坦、左氧氟沙星、头孢他啶敏感性高，可优先选用。对铜绿假单胞菌：本院整体耐药率较低；环丙沙星、左氧氟沙星、头孢他啶、哌拉西林/他唑巴坦敏感性高，可优选。结论：临床医生应高度重视抗菌药物细菌耐药性分析结果，并根据分析结果科学选用抗菌药物，以最终达到安全、有效治疗感染性疾病的目的。更多还原

【Abstract】 Objective:To summarize the situation of antimicrobial drug bacterial resistance in the 4th quarter of 2020 in Zigong First People’s Hospital and conduct an in-depth analysis, and propose countermeasures and recommendations to promote the rational use of antimicrobial drugs, so as to provide guidance and reference for the rational clinical use of antimicrobial drugs.Methods:Whonet 5.6 was used to statistically analyze the antimicrobial drug sensitivity test data of the hospital in the 4th quarter of 2020. At the same time, according to the Guidelines for Clinical Application of Antibacterial Drugs and the Management Measures for Clinical Application of Antibacterial Drugs, early warning alerts were made for antibacterial drug varieties with bacterial resistance over 30%, and antibacterial drugs with high bacterial susceptibility were screened out and recommended for clinical priority.Results:Penicillin was more than 75% resistant to Staphylococcus aureus and should be avoided. Levofloxacin, ciprofloxacin, and benzocillin were highly susceptible and could be used in preference. Erythromycin was more than 75% resistant to Streptococcus pneumoniae and should be avoided. Levofloxacin, amoxicillin, ceftriaxone and cefotaxime were highly sensitive and could be preferred. Ampicillin was more than 75% resistant to E. coli and should be avoided. Amikacin and piperacillin/tazobactam had98.40% and 97.6% susceptibility and could be preferred. Commonly used antimicrobial drugs in hospitals bacterial resistance to Klebsiella pneumoniae was low, piperacillin/tazobactam, levofloxacin and ceftazidime were highly sensitive and could be used in preference. The hospital had a low rate of resistance to Pseudomonas aeruginosa, and ciprofloxacin, levofloxacin, ceftazidime, and piperacillin/tazobactam were highly susceptible and may be preferred.Conclusion:Clinicians should attach great importance to the results of antimicrobial drug bacterial resistance analysis and select antimicrobial drugs scientifically according to the analysis results in order to ultimately achieve the purpose of safe and effective treatment of infectious diseases.更多还原