【摘要】 目的 评价天然外用制剂预防产妇母乳喂养期间乳头皲裂的效果。方法 计算机检索万方数据库、中国知网、中国生物医学文献数据库、维普网、PubMed、Embase、Cochrane Library、Web of Science中所有天然外用制剂防治乳头皲裂的随机对照试验，检索时限为建库至2022年8月12日。结果 共纳入研究19篇，总样本量2 590例，涉及13种干预措施。网状Meta分析结果显示，预防效果最佳的天然外用制剂依次为胎脂、橄榄油、小麻油、绵羊醇唇膏、蛋黄油、薄荷、加味玉屏风散、羊脂膏等；效果最差的为常规护理(温水清洁与健康教育)、乳汁等。结论 推荐临床使用天然外用制剂中的胎脂、橄榄油等进行乳头皲裂的预防护理。更多还原

【Abstract】 Objective To evaluate effect of natural external preparations on prevention of maternal cracked nipples during breastfee-ding.Methods We searched WanFang data, CNKI, CBM, VIP, PubMed, Embase, Cochrane Library and Web of Science for randomized controlled trials(RCTs) regarding natural external preparations for the prevention and treatment of maternal cracked nipples, with the trials being published from database inception to August 12, 2022.Results A total of 19 studies were finally obtained, with a total sample size of 2 590 cases, involving a total of 13 intervention methods.Network meta-analysis results showed that the natural external preparations with best preventive effect in descending orders were vernix caseosa, olive oil, sesame oil, lanolin lip balm, egg yolk oil, peppermint, Yupingfeng powder, lanolin cream, etc; the least effective interventions were routine nursing care(warm water cleansing and education), breast milk usage.Conclusion The results of network meta-analysis recommended the clinical use of natural external preparations of vernix caseosa, olive oil, etc., for preventive care of cracked nipples.更多还原