【摘要】 2型糖尿病(T2DM)是由遗传与环境因素共同作用引起的胰岛素分泌和(或)利用障碍所致的以慢性高血糖为特征的代谢性疾病，发病机制主要是胰岛β细胞功能障碍和胰岛素抵抗，越来越多的研究发现组织相关基因甲基化状态的改变参与T2DM发生发展。姜黄素能够改善胰岛素抵抗及胰岛β细胞功能，并且姜黄素作为甲基化抑制剂，能够通过下调靶基因甲基化水平发挥去甲基化作用。本文对姜黄素和甲基化调控胰岛素抵抗、胰岛β细胞功能相关基因的相关进展进行阐述。更多还原

【Abstract】 Type 2 diabetes mellitus(T2DM) is a metabolic disease characterized by chronic hyperglycemia caused by disturbance of insulin secretion and(or)utilization caused by genetic and environmental factors. The pathogenesis is mainly islet β-cell dysfunction and insulin resistance. More and more studies have found that changes in methylation status of tissue-related genes are involved in the occurrence and development of T2DM. Curcumin can improve insulin resistance and islet β-cell function, and curcumin, as a methylation inhibitor, can play a demethylation role by down-regulating the methylation level of target genes. This paper reviews the progress of curcumin and methylation in regulating insulin resistance and islet β-cell function related genes.更多还原