【摘要】 目的 探讨高浓度PM_2.5对2型糖尿病患者新发糖尿病视网膜病变（diabetic retinopathy,DR）风险的影响。方法 收集石家庄市2015年1月1日至2018年12月31日新发DR患者日就诊发病资料,采用分布滞后非线性模型（distributed lag non-linear models,DLNM）分析PM_2.5对DR的累积效应和滞后效应。结果 2015—2018年石家庄市新发DR患者6 123例,日均PM_2.5浓度中位数为64μg/m³,DR日就诊量与PM_2.5浓度呈非线性关系。当PM_2.5浓度超过64μg/m³时,PM_2.5每上升10μg/m³,DR发生风险上升4.91%（RR=1.049,95%CI:1.013～1.091）,14 d累积风险增加20.9%（RR=1.209,95%CI:1.092～1.339）。结论 高浓度PM_2.5与DR风险增加有关,应减少糖尿病患者雾霾天气室外暴露的频次和时间。更多还原

【Abstract】 Objective To understand the effect of atmospheric high concentration PM_2.5 on new-onset diabetic retinopathy（DR）in patients with type 2 diabetes mellitus.Methods The daily data of new-onset DR patients and the corresponding atmospheric PM_2.5 data were collected in Shijiazhuang during January 1,2015 and December 31,2018,and the cumulative effect and lag effect of PM_2.5 on DR were analyzed by distributed lag non-linear models（DLNM）.Results There were 6 123new-onset patients of DR in Shijiazhuang from 2015 to 2018,and the daily visits of DR had a nonlinear relationship with PM_2.5.Daily concentration of PM_2.5 was as high as 64 μg/m³.When the concentration of PM_2.5 exceeded the median concentration of 64μg/m³,every 10 μg/m³ increase of PM_2.5 will lead to 4.91%（RR=1.049,95%CI:1.013-1.091） increase of the risk of DR,and the 14 day cumulative risk increased by 20.9%（RR=1.209,95% CI:1.092-1.339）.Conclusion High concentration of PM_2.5may increase the risk of new-onset diabetic retinopathy.Patients with type 2 diabetes mellitus need to reduce the frequency and time of outdoor exposure in haze weather.更多还原