【摘要】 为探索3-亚烷基异吲哚啉-1-酮在有机合成中的应用潜力，构建新型的异吲哚啉-1-酮类化合物，本文以3-亚烷基异吲哚啉-1-酮和醇为原料，在三氯硅烷与路易斯碱催化剂作用下发生加成反应，得到一系列3-烷氧基-3-烷基异吲哚啉-1-酮类化合物，并初步尝试了以手性路易斯碱催化该反应。综上，本文建立了一种新型异吲哚啉-1-酮类化合物的合成方法，该方法条件具有温和、操作便捷、底物适用范围广和收率普遍较高的特点。更多还原

【Abstract】 In order to explore the potential of 3-alkyleneisoindoline-1-ones in organic synthesis and construct new isoindoline-1-one derivatives, addition of 3-alkyleneisoindoline-1-ones with alcohols was conducted in the presence of trichlorosilane and Lewis base catalyst. A wide variety of 3-alkoxy-3-alkyl-isoindoline-1-ones were prepared by this transformation. Moreover, a catalytic asymmetric version of this reaction was explored. In brief, a method of preparation of new isoindoline-1-one derivatives has been established. This method features mild conditions, easy handling, wide substrate tolerance and generally good yields.更多还原