【摘要】 目的 探讨血浆半乳糖凝集素3(galectin-3,Gal-3)水平与2型糖尿病(type 2 diabetes mellitus, T2DM)合并冠心病(coronary artery disease, CAD)的相关性。方法 选取T2DM患者60例设为T2DM组，T2DM合并CAD患者60例设为T2DM+CAD组。收集患者病程、年龄等数据。酶联免疫吸附测定(enzyme-linked immunosorbent assay, ELISA)法检测两组血浆Gal-3水平，同时明确血浆Gal-3水平与心脏射血分数、糖化血红蛋白、C反应蛋白等指标的相关性。结果 T2DM与T2DM+CAD组患者年龄、性别、吸烟情况、饮酒情况以及血脂等生化指标差异无统计学意义。与T2DM组相比，T2DM+CAD组患者血浆Gal-3明显升高(P<0.01),且血浆Gal-3水平与高密度脂蛋白水平呈负相关(P<0.05)。多元线性回归分析显示糖化血红蛋白、C反应蛋白是血浆Gal-3的影响因素。Logistic回归分析显示血浆Gal-3水平、年龄是CAD发生的影响因素。结论 T2DM+CAD患者血浆Gal-3水平明显升高，可能是T2DM患者发生CAD的影响因素。更多还原

【Abstract】 Objective To investigate the correlation between plasma galectin-3(Gal-3) level and type 2 diabees mellitus(T2DM) complicated with coronary artery disease(CAD). Methods Sixty patients with T2DM(T2DM group) and 60 patients with T2DM and CAD(T2DM+CAD group) were enrolled in this study. Patients’ data including course of disease and age were collected. Left ventricular ejection fraction was assessed by echocardiography. Enzyme-linked immunosorbent assay(ELISA) was used to measure plasma Gal-3 levels in the two groups. The correlation of Gal-3 levels with cardiac ejection fraction, glycosylated hemoglobin and C-reactive protein(CRP) was analyzed. Results There was no significant difference in age, gender, smoking, alcohol consumption, and biochemical indicators such as blood lipids between the T2DM and T2DM+CAD groups. Compared with that in T2DM patients, plasma Gal-3 level was significantly increased in patients with T2DM+CAD(P<0.01). Plasma Gal-3 level was negatively correlated with high-density lipoprotein(HDL) level(P<0.05). Multiple linear regression analysis showed that glycosylated hemoglobin and CRP were influencing factors for plasma Gal-3 levels. Logistic regression analysis showed that plasma Gal-3 level and age were the risk factors influencing the occurrence of CAD in T2DM patients. Conclusion Plasma Gal-3 level is significantly increased in T2DM+CAD patients, which may be an influencing factor for the occurrence of CAD in T2DM patients.更多还原