【摘要】 帕金森病（PD）是第二大神经退行性疾病，其致病机制与黑质（SN）中的多巴胺神经元严重丢失、α-突触核蛋白的大量积累有关。钾（K~+）通道在中枢神经系统中广泛分布，在调节细胞兴奋性、突触传递和神经递质的释放中起关键作用。大量文献表明PD发生与K~+通道功能异常密切相关，PD也被认为是离子通道疾病。近年来的研究显示，干预K~+通道可以显著影响PD患者的运动和非运动障碍。本文对K~+通道在PD中的作用进行了综述，总结并讨论了干预K~+通道在PD治疗中的影响，为PD的预防和治疗提供新思路。更多还原

【Abstract】 Parkinson’s disease is the second commonest neurodegenerative disease. Its pathogenic mechanism is related to the severe loss of dopaminergic neurons in the substantia nigra and the large accumulation of α-synuclein. Potassium channels are widely distributed in the central nervous system and play a key role in regulating cell excitability, synaptic transmission and neurotransmitter release. A large number of literature show that the occurrence of Parkinson’s disease is closely related to the abnormal function of potassium channels. Also, Parkinson’s disease is also considered to be an ion channel disease. Recent studies show that regulation of potassium channels can significantly affect the movement and non-motor disorders of Parkinson’s disease. In this review, the authors summarized the roles of potassium channels in Parkinson’s disease and discussed the impact of intervention of potassium channels in the treatment of Parkinson’s disease to provide new ideas for the prevention and treatment of Parkinson’s disease.更多还原