【摘要】 目的 建立一种简便、灵敏的测定方法来检测甲磺酸达比加群酯胶囊的含量。方法 采用高效液相色谱法测定甲磺酸达比加群酯胶囊中主药的含量，色谱柱：ODS C₁₈（250 mm×4.6 mm, 5μm）,流动相∶甲醇-水（75∶25,水中加0.1%三乙胺）,检测波长：323 nm,流速：1.0 mL·min^-1;柱温：35℃;进样体积：10μL。结果 甲磺酸达比加群酯在0.5～10μg·mL^-1范围内线性关系良好（R²=0.9999）,平均回收率为98.93%,RSD为0.46%。结论 该方法操作便捷、灵敏度高，结果准确，可用于甲磺酸达比加群酯胶囊中甲磺酸达比加群酯的含量测定。更多还原

【Abstract】 OBJECTIVE To establish a simple, sensitive determination of dabigatran etexilate mesylate capsules.METHODS HPLC method was adopted.The separation was performed on a ODS C₁₈（250 mm×4.6 mm, 5 μm）,column with mobile phase consisted of methanol-water（75∶25,0.1% triethylamine in water） and the detection wavelength was 323 nm.The flow rate was 1.0 mL·min^-1.The column temperature was 35 ℃.The injection volume was 10 μL.RESULTS The linear range of dabigatran etexilate mesylate was 0.5-10 μg·mL^-1（R²=0.9999）.The average recovery was 98.93%（RSD=0.46%,n=9）.CONCLUSION The method is simple and accurate, which can be used in the quantitative determination of dabigatran etexilate mesylate in capsules.更多还原