【摘要】 结直肠癌是一种常见的恶性肿瘤，其早期症状不典型，通常在晚期才被诊断出来，由于手术、化疗等常规治疗效果不佳，死亡率极高。铜是一种矿物质营养素，铜含量在体内维持动态平衡，参与机体多种生物学过程，铜稳态被打破可引起铜代谢相关疾病和癌症的发生。铜可通过氧化应激、抑制泛素-蛋白酶体系统、抑制血管生成以及最新提出的铜死亡等方式来介导肿瘤细胞死亡，异常的铜水平成为癌症治疗的新目标。本文针对铜介导肿瘤细胞死亡的机制以及其在结直肠肿瘤治疗中的研究进展做一简要综述。更多还原

【Abstract】 Colorectal cancer is a common malignant tumor with atypical early symptoms and is usually diag-nosed at an advanced stage, with a very high mortality rate due to the ineffectiveness of conventional treatments such as surgery and chemotherapy. Copper is a mineral nutrient that maintains a dynamic balance in the body and is involved in a variety of biological processes. Disruption of copper homeostasis can cause copper metabolism-related diseases and cancer development. Copper can mediate tumor cell death through oxidative stress, inhibition of the ubiquitin-protea-some system, inhibition of angiogenesis and, most recently, proposed copper death, and abnormal copper levels have be-come a new target for cancer therapy. This article provides a brief review of the mechanisms by which copper mediates tumor cell death and the progress of its research in the treatment of colorectal tumors.更多还原