【摘要】 目的 调查育龄期女性胚胎停育发生率及影响因素。方法 于2018年1月至2020年12月期间，对在咸阳市三家医院妇产科就诊的8 693例育龄期孕妇进行前瞻性研究调查，了解胚胎停育发生情况，并采用多因素Logisitic回归分析胚胎停育的危险因素。结果 2020年胚胎停育发生率为2.71%(77/2 845)，明显高于2018年的1.85%(51/2 751)，差异有统计学意义(P<0.05)；≥30岁、服用紧急避孕药、经常吸烟、使用手机/电脑时间>8 h、孕前3个月/孕期烫染发、喝酒、合并焦虑孕妇胚胎停育发生率分别为2.65%、3.50%、3.65%、2.58%、3.94%、2.76%、4.45%，明显高于<30岁、未服用紧急避孕药、偶尔或无吸烟或/动吸烟、使用手机/电脑时间4～8 h或<4 h、孕前3个月/孕期未烫染发、无喝酒、无焦虑者胚胎停育的发生率(分别为1.82%、2.12%、1.95%、1.82%、1.99%、1.90%、2.01%)，差异均有统计学意义(P<0.05)；经多因素logistic回归分析结果显示，孕前3个月/孕期烫染发、吸烟/被动吸烟、合并焦虑是胚胎停育发生的独立危险因素(P<0.05)。结论 育龄期女性妇女胚胎停育的发生率呈逐年上升趋势，孕前3个月/孕期烫染发、吸烟/被动吸烟、合并焦虑是疾病发生的独立危险因素。更多还原

【Abstract】 Objective To investigate the incidence and influencing factors of embryo damage in childbearing age women. Methods A prospective study was performed on 8 693 childbearing age women treated in Department of Obstetrics and Gynecology of three hospitals in Xianyang between January 2018 and December 2020. The occurrence of embryo damage was understood, and the risk factors of embryo damage were analyzed by multivariate Logisitic regression analysis. Results The incidence of embryo damage in 2020 was significantly higher than that in 2018: 2.71%(77/2 845) vs 1.85%(51/2 751), P<0.05. The incidence rates of embryo damage in pregnant women with age ≥30 years,use of emergency contraceptives, frequent smoking, use time of mobile phone/computer>8 h, hair perming and dying at3 months before pregnancy/during pregnancy, drinking, and anxiety were 2.65%, 3.50%, 3.65%, 2.58%, 3.94%, 2.76%,and 4.45%, significantly higher than 1.82%, 2.12%, 1.95%, 1.82%, 1.99%, 1.90%, 2.01% in pregnant women with age <30 years, no use of emergency contraceptives, occasional smoking/non-smoking/passive smoking, use time of mobile phone/computer within 4-8 h or <4 h, no hair perming and dying at 3 months before pregnancy/during pregnancy, no drinking, and no anxiety, P<0.05. The results of multivariate Logistic regression analysis showed that hair perming and dying at 3 months before pregnancy/during pregnancy, smoking/passive smoking, and anxiety were independent risk factors of embryo damage(P<0.05). Conclusion The incidence of embryo damage in childbearing age women is increasing year by year. Hair perming and dying at 3 months before pregnancy/during pregnancy, smoking/passive smoking,and anxiety are independent risk factors of embryo damage.更多还原