【摘要】 目的 以卡波姆940(C-940)为基质，将水难溶性中药黄酮成分光甘草定制备成醇质体凝胶，为难溶性中药的皮肤给药制剂研究提供思路与借鉴。方法 选用C-940作为乙醇、丙二醇、混合醇（乙醇-丙二醇2∶8）三种光甘草定醇质体凝胶基质，对光甘草定醇质体凝胶进行体外评价。结果 C-940浓度为0.4%，所得光甘草定醇质体凝胶呈淡黄色，无分层，黏稠度适中，适宜涂抹。乙醇醇质体凝胶、丙二醇醇质体凝胶、混合醇醇质体凝胶中光甘草定的含量分别为643.09、414.79、615.08μg/g,12 h累积释放量分别为11.11、7.03、6.30μg/cm~2，与醇质体释放规律一致，没有改变光甘草定的释放行为。光甘草定醇质体凝胶和凝胶基质对大鼠皮肤都没有刺激性，较安全。结论 以C-940制备的光甘草定醇质体凝胶能有效地改善光甘草定的水溶性，安全性良好。为进一步开发相关的皮肤外用制剂提供基础。更多还原

【Abstract】 Objective To prepare ethosome gel from glabridin, a water-insoluble flavonoid component of Chinese materia medica, with Carbomer 940(C-940) as the substrate, so as to provide ideas and references for the investigation of skin administration preparations of insoluble Chinese materia medica. Methods C-940was selected as the substrate of three kinds of glabridin ethosome gels, including ethanol, propylene glycol and mixed alcohol(the proportion of ethanol to propylene glycol was 2 ∶ 8), and the glabridin ethosome gels were evaluated in vitro. Results When the concentration of C-940 was 0.4%, the obtained glabridin ethosome gel was light yellow, without delamination, with moderate viscosity and suitable for smearing. The contents of glabridin in ethanol ethosome gel, propylene glycol ethosome gel and mixed ethosome gel were 643.09,414.79 and 615.08 μg/g respectively, and the cumulative release amounts for 12 hours were 11.11, 7.03and 6.30 μg/cm~2 respectively, which were consistent with the release law of ethosomes, and did not change the release behavior of glabridin. Both glabridin ethosome gel and gel substrate had no irritation to rat skin and were relatively safe. Conclusion The glabridin ethosome gel prepared by C-940 can effectively improve the water solubility of glabridin and has good safety. Therefore, it provides a basis for further development of related external preparations for skin.更多还原