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抗生素佐剂在治疗鲍曼不动杆菌感染中的研究进展

Research Progress of Antibiotic Adjuvants in the Treatment of Acinetobacter baumannii Infection

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【作者】 张梦娜赵晓欧许祺珺孔令聪马红霞

【Author】 Zhang Meng-na;Zhao Xiao-ou;Xu Qi-jun;Kong Ling-cong;Ma Hong-xia;College of Veterinary Medicine,Jilin Agricultural University;The Key Laboratory of New Veterinary Drug Research and Development of Jilin Province;College of Life Science,Jilin Agricultural University;Bioreactor and Drug Development Engineering Research Center of Ministry of education,Jilin Agricultural University;

【通讯作者】 马红霞;

【机构】 吉林农业大学动物医学院吉林省新兽药研发与创制重点实验室吉林农业大学生命科学学院吉林农业大学生物反应器与药物开发教育部工程研究中心

【摘要】 目前鲍曼不动杆菌感染治疗困难与多重耐药、广泛耐药菌株的出现以及革兰阴性菌新型抗菌药物缺乏有关。为了治疗和控制鲍曼不动杆菌严重感染,新的用药选择不可或缺。佐剂通过增效抗生素,逆转耐药,克服了现有药物治疗的局限性。本文将可增敏鲍曼不动杆菌的抗生素佐剂加以汇总,拟为临床防治相关感染提供理论依据。

【Abstract】 At present, the difficulties in the treatment of Acinetobacter baumannii infection are related to the emergence of multidrug-resistant bacteria and extensively drug-resistant bacteria, as well as the lack of new antibiotics for Gram-negative bacteria. Therefore, it is necessary to make new drug choices for the treatment and control of serious Acinetobacter baumannii infection. Adjuvants have the ability to overcome the drawbacks of current drug therapy by sensitizing antibiotics and reversing drug resistance. In order to provide a theoretical foundation for the practical prevention and treatment of associated illnesses, this paper describes the antibiotic adjuvants that boost the antibacterial activity against Acinetobacter baumannii.

【基金】 国家自然科学基金项目(31872519)
  • 【文献出处】 国外医药(抗生素分册) ,World Notes on Antibiotics , 编辑部邮箱 ,2023年06期
  • 【分类号】R446.5
  • 【下载频次】47
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