【摘要】 针对L-硒-甲基硒代半胱氨酸的合成存在操作安全系数低、后处理成本高的问题，研究开发一种新的合成方法。通过小试获得优化的工艺条件，设计并搭建中试生产线，以验证合成工艺稳定性。小试研究结果表明：L-丝氨酸经氯化获得3-氯-L-丙氨酸盐酸盐(产率：89.7%)、再与三乙酰氧基硼氢化钠法制备的二硒化二钠反应生成L-硒代胱氨酸(产率：73.0%)、最后在反应物L-硒代胱氨酸、碘甲烷、三乙酰氧基硼氢化钠物质的量比=1.00:4.02:1.58条件下经还原、甲基化获得目标产物(产率：78.3%)。在相同的工艺条件下，中试可以获得与小试接近或更高的产率，为L-硒-甲基硒代半胱氨酸的工业化生产奠定坚实基础。更多还原

【Abstract】 The synthesis of L-selenium-methylselenocysteine（L-SeMC） has problems of low safety factor and high cost of post-treatment. A new synthetic method was proposed in this study. Optimized process conditions were first obtained in laboratory, and then a pilot production line was designed and built to verify the process stability. The laboratory results show that L-serine is chlorinated to obtain 3-chloro-L-alanine hydrochloride（yield: 89.7%）, and then reacts with sodium diselenide by sodium triacetoxyborohydride reduction to generate L-selenocystine（L-SeC₂）（yield: 73.0%）. The target product is finally obtained by reduction and methylation under the molar ratio of n（L-SeC₂）:n（iodomethane）:n（sodium triacetoxyborohydride）=1.00:4.02:1.58（yield:78.3%）. The yields of the pilot production line are close to or higher than that of the laboratorial results, which helps for the industrial production of L-SeMC.更多还原