【摘要】 目的 探究舍曲林治疗缺血性卒中后抑郁患者的效果及其对认知功能及血清神经递质的影响。方法 选取我院2020年7月～2021年12月期间109例缺血性卒中后抑郁患者作为研究对象，采用随机数字表法分为传统组和联合组。传统组54例给予常规治疗，联合组55例在常规治疗基础上加用盐酸舍曲林治疗，对比两组患者抑郁情绪，认知功能，血清神经递质，不良反应。结果联合组治疗4周后汉密尔顿抑郁量表、Zung抑郁自评量表、美国国立卫生院卒中量表评分及血清孤腓肽（OFQ）水平低于传统组；简明智力状态检查（MMSE）评分及血清5-羟色胺水平高于传统组（P<0.05）。经Fisher确切概率法检验，联合组不良反应发生率5.45%与传统组1.85%经比较无差异（P>0.05）。结论 舍曲林可改善缺血性卒中后抑郁患者认知功能，调节抑郁情绪，改善血清神经递质，安全性较高。更多还原

【Abstract】 Objective To explore the effect of sertraline hydrochloride in the prophylactic treatment of ischemic stroke patients with depression and its effect on cognitive function and serum neurotransmitter. Methods A total of 109 patients with ischemic stroke depression in our hospital from July 2020 to December 2021 were selected as research objects,and were divided into traditional group and combined group by random number table method. Fifty-four patients in the traditional group received conventional treatment,and 55 patients in the combined group received low dose sertraline hydrochloride on the basis of conventional treatment. The depression,cognitive function,serum neurotransmitter and adverse reactions were compared between the two groups. Results After 4 weeks of treatment,the Hamilton Depression Scale,Zung Self-Rating Depression Scale,National Institutes of Health Stroke Scale scores and serum Orphanin-FQ levels in the combined group were lower than those in the traditional group. MMSE score and serum 5-hydroxytryptamine level were higher than those in the traditional group(P<0.05). By Fisher’s exact probability test,there was no difference in the incidence of adverse reactions between the combined group(5.45%)and the traditional group(1.85%)(P>0.05). Conclusion Sertraline can improve cognitive function,regulate depressive mood and improve serum neurotransmitter in patients with ischemic stroke depression,with high safety.更多还原