【摘要】 胶质母细胞瘤是中枢神经系统中一种具有高度侵袭性的恶性肿瘤，其发病机制尚不明确，且缺乏特异性的诊疗措施，病死率仍然居高不下。因此，亟须探索胶质瘤扩散、浸润的机制和开发新型治疗措施。上皮间质转化（EMT）在胶质瘤扩散、浸润的调控中发挥关键作用，已被证实与胶质瘤侵袭、迁移和治疗抵抗有关，而Wnt/β-catenin信号通路可介导EMT参与人体多种病理生理过程，此外，微小RNA可以与EMT相互作用进而影响细胞的生物学行为。该文通过综述Wnt/β-catenin信号通路对胶质瘤EMT的影响及针对该进程不同的干预措施，为该领域的研究提供参考。[国际神经病学神经外科学杂志, 2023, 50(6):78-83]更多还原

【Abstract】 Glioblastoma is a highly aggressive malignant tumor in the central nervous system with an extremely poor prognosis. The pathogenesis of this disease is not fully understood and the mortality remains high due to the lack of specific diagnosis and treatment methods. Therefore, it is urgent to explore the mechanism of glioma spread and infiltration and develop novel treatments. Epithelial-mesenchymal transition(EMT) plays a key role in regulating the spread and infiltration of glioma, and has been proven to be associated with glioma invasion, migration, and therapeutic resistance.The Wnt/β-catenin signaling pathway can play a role in a range of pathophysiological processes via EMT. Furthermore, microRNAs can interact with EMT and influence cellular processes. This article reviews the effects of the Wnt/β-catenin signaling pathway on glioma EMT and different interventions for this process, providing theoretical basis and reference for preventing the EMT in glioma. [Journal of International Neurology and Neurosurgery, 2023, 50(6): 78-83]更多还原