【摘要】 孤独症谱系障碍是一种神经发育障碍性疾病，主要表现为缺乏社会交流和互动能力，同时伴有重复刻板行为。近年来研究发现孤独症谱系障碍患者常可伴有胃肠功能异常，同时国内外部分研究发现孤独症谱系障碍患者肠道菌群构成与健康儿童相比发生了显著变化。但其具体机制仍不明确，甚至出现了相反的结论。该文通过回顾相关文献资料，从微生物―肠―脑轴角度出发，着重从肠道代谢产物异常、免疫失衡及神经发育角度对肠道菌群介导的免疫失衡在孤独症谱系障碍发病机制中的作用进行综述。[国际神经病学神经外科学杂志,2023,50(4):65-70]更多还原

【Abstract】 Autism spectrum disorder(ASD) is a neurodevelopmental disorder characterized by a lack of social communication and interaction and the presence of repetitive stereotyped behaviors.In recent years,studies have shown that patients with ASD often have abnormal gastrointestinal function,and some studies have found that compared with healthy children,there are significant changes in the composition of gut microbiota in patients with ASD.However,the specific mechanism remains unclear,and even opposite conclusions have been obtained.Based on related literature,this article reviews the role of gut microbiota-mediated immune imbalance in the pathogenesis of ASD from the perspective of the microbial-gut-brain axis,abnormal gut metabolites,immune imbalance,and neurodevelopment.[Journal of International Neurology and Neurosurgery,2023,50(4):65-70]更多还原