【摘要】 目的 观察沙库巴曲缬沙坦在老年糖尿病肾病(DN)患者中的有效性及安全性。方法选取2022年1～12月吉林市人民医院和吉林大学第二医院诊断为DN的120例患者进行回顾性分析，根据治疗方案，将患者分为对照组(使用缬沙坦)及观察组(使用沙库巴曲缬沙坦),各60例。比较两组的年龄、性别、收缩压、估算肾小球滤过率(eGFR)、24 h尿蛋白、血钾、白细胞介素6(IL-6)、C反应蛋白(CRP)、左室射血分数(LVEF)及糖化血红蛋白等一般及临床资料。结果 治疗后观察组eGFR及LVEF水平明显高于治疗前(P<0.05),收缩压、24 h尿蛋白、IL-6、CRP及糖化血红蛋白水平明显低于治疗前(P<0.05),观察组血钾水平治疗前后差异无统计学意义(P>0.05);治疗后观察组eGFR及LVEF水平明显高于对照组(P<0.05),收缩压、24 h尿蛋白、血钾、IL-6、CRP及糖化血红蛋白水平明显低于对照组(P<0.05)。结论 DN患者使用沙库巴曲缬沙坦，可以更好地延缓肾脏功能恶化，改善心血管功能，减轻机体炎症反应，对血钾影响较小，同时有利于血糖调控。更多还原

【Abstract】 Objective To observe the efficacy and safety of sacubitril-valsartan in elderly patients with diabetic nephropathy.Methods A total of 120 patients diagnosed with diabetic nephropathy in Jilin People’s Hospital and the Second Hospital of Jilin University from January to December 2022 were selected and retrospectively analyzed.According to the treatment plan, the patients were divided into the control group(using valsartan) and the observation group(using sacubitril valsartan),with 60 cases in each group.General and clinical data such as age, gender, systolic blood pressure, estimated glomerular filtration rate(eGFR),24 h urinary protein, serum potassium, interleukin-6(IL-6),C-reactive protein(CRP),left ventricular ejection fraction(LVEF) and glycosylated hemoglobin were compared between the two groups.Results After treatment, eGFR and LVEF levels in observation group were significantly higher than those before treatment(P<0.05),systolic blood pressure, 24 h urine protein, IL-6,CRP and glycosylated hemoglobin levels were significantly lower than those before treatment(P<0.05),and there was no significant difference in serum potassium level before and after treatment in observation group(P>0.05);after treatment, eGFR and LVEF levels in observation group were significantly higher than those in control group(P<0.05),and systolic blood pressure, 24 h urine protein, serum potassium, IL-6,CRP and glycosylated hemoglobin levels were significantly lower than those in control group(P<0.05).Conclusion The use of sacubitril-valsartan in patients with diabetic nephropathy can better delay the deterioration of renal function, improve cardiovascular function, reduce the body inflammatory response, have less effect on serum potassium, and facilitate blood glucose regulation.更多还原