【摘要】 光散射法是区分正常和病变血红细胞的有效方法，然而当前缺少对于病变血红细胞建模和光散射特性的研究。本文以反常衍射近似理论为基础构建了正常双凹圆饼形血红细胞以及病变椭圆形、镰刀型和聚集血红细胞的光散射模型，确定了该理论应用于血红细胞时的适用角度范围，应用数值仿真探究了异常形态、异常尺寸和异常聚集血红细胞与正常血红细胞的光散射空间分布的差异。仿真结果表明，不同半径和形态血红细胞的散射光强曲线的极值个数和对应角度均有较大差异，而聚集血红细胞散射曲线的极小值对应的角度基本一致，极小值大小有22%以上的差距。这一结论对于使用光散射法检测和区分正常和病变血红细胞以及建立血红细胞形貌特征反演算法有重要意义。更多还原

【Abstract】 Light scattering is an effective method to distinguish normal and diseased red blood cells. However, there is a lack of research on the modeling and light scattering characteristics of diseased red blood cells. Based on the abnormal diffraction approximation theory, this paper constructs the light scattering models of normal double concave pancake shaped red blood cells and diseased oval, sickle shaped and aggregated red blood cells, determines the applicable angle range of this theory when applied to red blood cells, and uses numerical simulation to explore the differences in the spatial distribution of light scattering between abnormal morphology, abnormal size and abnormal aggregated red blood cells and normal red blood cells. The simulation results show that there are great differences in the extreme number and corresponding angle of the scattered light intensity curve of red blood cells with different radius and shape, while the angle corresponding to the minimum value of the scattered light intensity curve of aggregated red blood cells is basically the same, and the minimum value has a gap of more than 22%. This conclusion is of great significance for detecting and distinguishing normal and diseased red blood cells by light scattering method and establishing an algorithm for retrieving the morphological characteristics of red blood cells.更多还原