【摘要】 目的 了解湖南省临床分离鲍曼不动杆菌的流行病学情况。方法 按照全国细菌耐药监测网技术方案要求开展细菌耐药监测工作，参考美国临床实验室标准化协会标准，对2012—2021年湖南省多中心上报至湖南省细菌耐药监测网的不动杆菌属的临床资料进行总结与分析。结果 10年间共检出不动杆菌属169 438株，其中以鲍曼不动杆菌检出最多(82.74%)。耐碳青霉烯类鲍曼不动杆菌(CRAB)和碳青霉烯类敏感鲍曼不动杆菌(CSAB)分别检出70 923株(53.63%)和58 149株(43.97%)。CRAB与CSAB均在>70岁年龄段中检出最多，分别为34.44%、32.02%;CRAB与CSAB在ICU中检出的占比分别为34.80%、11.31%。CRAB与CSAB主要分离自痰/支气管肺泡灌洗液，其次为脓/分泌物、尿、血。10年间CRAB对常用抗菌药物的耐药率变化不大。CRAB对头孢他啶和头孢吡肟的耐药率均>84%;对氨苄西林/舒巴坦、哌拉西林/他唑巴坦的耐药率均>82%;对氨基糖苷类、喹诺酮类药物耐药率均>59%;对米诺环素、多黏菌素B的耐药率分别为15.9%～25.0%、1.3%～6.9%。CSAB对常用抗菌药物均较敏感。结论 CRAB分离率较高，对常用抗菌药物的耐药性无明显变化。更多还原

【Abstract】 Objective To understand the epidemiology of clinically isolated Acinetobacter baumannii(A. bauma-nnii) in Hunan Province. Methods Bacterial antimicrobial resistance surveillance was carried out according to the requirements of the technical program of National Antimicrobial Resistance Surveillance System. Clinical data of Acinetobacter spp. reported to Hunan Provincial Antimicrobial Resistance Surveillance System by multiple centers in Hunan Province from 2012 to 2021 were summarized and analyzed with reference to the standards of the American Clinical and Laboratory Standards Institute. Results A total of 169 438 strains of Acinetobacter spp. were detected during the 10-year period, with the detection rate of A. baumannii being the highest(82.74%). 70 923 strains(53.63%) of carbapenem-resistant A. baumannii(CRAB) and 58 149 strains(43.97%) of carbapenem-sensitive A. baumannii(CSAB) were detected respectively. Both CRAB and CSAB were detected most frequently in the age group >70 years, which were 34.44% and 32.02%, respectively. The percentage of CRAB and CSAB detected in the intensive care unit were 34.80% and 11.31%, respectively. CRAB and CSAB were mainly isolated from sputum/bronchoalveolar lavage fluid, followed by pus/secretion, urine, and blood. The resistance rates of CRAB to commonly used antimicrobial agents didn’t change much during the 10-year period. Resistance rates of CRAB to ceftazidime and cefepime were both >84%, to ampicillin/sulbactam and piperacillin/tazobactam were both >82%, to aminoglycosides and quinolones were both >59%, to minocycline and polymyxin B were 15.9%-25.0% and 1.3%-6.9%, respectively. CSAB were sensitive to commonly used antimicrobial agents. Conclusion The isolation rate of CRAB is high and there is no significant change in resistance to commonly used antimicrobial agents.更多还原