【摘要】 播散性隐球菌病主要是由隐球菌引起的全身不连续的两个及以上部位感染的疾病，其临床表现多样，常诊断困难。某院收治1例因“腹胀、间断低热2个月，身目黄染1个月，高热伴头痛11 d”入院的34岁女性患者，该患者无免疫力低下情况，病程中患者最先表现为腹胀、身目黄染、间断低热，继而出现高热、头痛，辅助检查发现胆管壁增厚并胆道梗阻，肺部渗出性病变，心内膜赘生物，纵膈、肝门、腹膜后多发淋巴结肿大，腰穿脑脊液压力>400 mmH₂O,脑脊液感染病原体宏基因组二代测序及培养均发现新生隐球菌，腹膜后淋巴结及肝脏病理检查均提示隐球菌感染，患者最终诊断为播散性隐球菌病。本文就该例病例进行分析，旨在提高临床对播散性隐球菌感染的认识。更多还原

【Abstract】 Disseminated cryptococcosis is a disease caused by Cryptococcus spp. that affects two or more non-adjacent body parts. The clinical manifestations of the disease are diverse, often leading to diagnostic challenges. A 34-year-old female patient was admitted to a hospital due to abdominal distension, intermittent low fever for 2 months, jaundice for 1 month, and high fever with headache for 11 days. The patient was not immunocompromised. During the disease course, the patient initially presented with abdominal distension, jaundice, and intermittent low fever, followed by high fever and headache. Auxiliary examination revealed thickened bile duct walls and biliary obstruction, pulmonary exudative lesions, endocardium vegetations, multi-lymph node enlargement in mediastinum, hepatic hilum and retroperitoneal space, cerebrospinal fluid pressure >400 mmH₂O on lumbar punctures. Meta-genomic next-generation sequencing（mNGS） and culture of cerebrospinal fluid detected Cryptococcus neoformans. Pathological examination of retroperitoneal lymph nodes and liver suggested Cryptococcus infection. The patient was ultimately diagnosed with disseminated cryptococcosis. The case analysis aims to enhance clinical understanding on disseminated cryptococcal infection.更多还原