【摘要】 Hippo信号通路是一条进化保守，可调节器官大小和细胞迁移、分化、增殖和凋亡的信号通路。在哺乳动物体内，Hippo通路通过多种保守激酶相互作用来调节器官大小和细胞迁移、分化、增殖和凋亡。研究发现，Hippo通路与缺血再灌注（Ischemia/Reperfusion, I/R）损伤密切相关，其核心组分哺乳动物Ste20样激酶1/2(Mammalian STE20-like kinase 1/2, Mst1/2)和Yes相关蛋白（Yes-associated protein, YAP）介导氧化应激、血脑屏障损伤、胶质细胞活化等过程，与线粒体动力学、细胞凋亡及瘢痕形成等紧密相关，参与I/R损伤的发生发展。因此，Mst1/2和YAP有望成为治疗I/R损伤的新靶点。本文以Mst1/2和YAP蛋白为研究核心，分别梳理Mst1/2和YAP蛋白在I/R损伤中的作用机制，为I/R损伤治疗寻找新思路。更多还原

【Abstract】 Hippo signaling is an evolutionarily conserved signaling pathway that regulates organ size and cell migration, differentiation, proliferation, and apoptosis. In mammals, the Hippo pathway regulates organ size and cell migration, differentiation, proliferation, and apoptosis through a variety of conserved kinase interactions. It was found that the Hippo pathway is closely related to ischemic reperfusion(I/R) injury, and its core components Mst1/2 and YAP proteins mediate oxidative stress, blood-brain barrier damage, activated glial cells and other processes, and are closely related to mitochondrial dynamics, apoptosis and scarring, and participate in the occurrence and development of I/R damage. Therefore, Mst1/2and YAP are expected to become new targets for the treatment of I/R damage. With Mst1/2 and YAP as the core, this paper combs the mechanism of Mst1/2 and YAP in I/R injury respectively, trying to develop new ideas for the treatment of I/R injury.更多还原