【摘要】 利用南极磷虾壳制备甲壳素，然后采用TEMPO氧化法将其制备成甲壳素纳米晶须，将不同添加量的甲壳素纳米晶须加入壳聚糖/鱼胶基体中，制备壳聚糖/鱼胶/甲壳素纳米晶须复合膜材料。通过扫描电镜(SEM)、透射电镜(TEM)、X射线衍射(XRD)和傅里叶红外光谱(FTIR)对甲壳素纳米晶须进行分析；通过SEM、光透射率、 XRD、热重分析(TG)对复合膜材料进行检测；通过小鼠皮下埋植实验对复合膜材料的降解性进行测试。研究结果表明，利用南极磷虾壳所制备的甲壳素纳米晶须呈针状或纤维状，平均直径为17 nm;甲壳素纳米晶须能够均匀分散在复合膜材料中，当甲壳素纳米晶须的添加量为7%时，复合膜的拉伸强度达到最大为18.37 MPa,相比于壳聚糖/鱼胶膜提高了160%,这说明纳米晶须添加到复合膜中能显著提高其机械强度。小鼠皮下降解实验表明，添加纳米晶须的复合膜降解速度变慢，第九周时，添加7%纳米晶须的膜材料降解率为66.2%。更多还原

【Abstract】 Chitin was prepared from Antarctic krill shells, and then it was prepared into chitin nano-whiskers by TEMPO oxidation method, and chitosan/fish glue/chitin nano-whisker composite film materials were prepared by adding different additions of chitin nano-whiskers into chitosan/fish glue matrix. The chitin nano-whiskers were analyzed by scanning electron microscopy(SEM), transmission electron microscopy(TEM), X-ray diffraction(XRD) and Fourier infrared spectroscopy(FTIR). The composite membrane materials were examined by SEM, optical transmittance, XRD and thermogravimetric analysis(TG), and the degradability of the composite membrane materials was tested by subcutaneous embedding experiments in mice. The results showed that the chitin nano-whiskers prepared from Antarctic krill shells were needle-like or fibrous with an average diameter of 17 nm. The chitin nano-whiskers were uniformly dispersed in the composite membrane material, and the tensile strength of the composite membrane reached a maximum of 18.37 MPa when the addition amount of chitin nano-whiskers was 7%, which was 160% higher than that of chitosan/fish glue membrane. This indicates that the addition of nano-whiskers into the composite film can significantly improve its mechanical strength. The subcutaneous degradation experiments in mice showed that the degradation rate of the composite membrane with nano-whisker addition became slower, and the degradation rate of the membrane with 7% nano-whisker addition was 66.3% at the ninth week.更多还原