【摘要】 目的 观察银杏达莫注射液联合丁苯酞氯化钠注射液在急性脑梗死（ACI）患者治疗中的应用效果、药理机制及安全性。方法 将ACI患者随机分为对照组和试验组。2组患者均给予基础对症治疗。对照组给予注射用瑞替普酶1 000万U静脉注射，0.5 h后重复上述剂量及操作1次；注射丁苯酞氯化钠注射液静脉滴注，25 mg·次^-1,bid;试验组在对照组基础上予以银杏达莫注射液静脉滴注，20 mL·次^-1,bid。2组均治疗10 d。比较治疗前后患者脑血流速度、血清神经损伤指标水平、血管内皮功能，对比2组治疗后的疗效，观察治疗期间药物不良反应发生情况。结果 最终对照组和试验组分别纳入40例和39例。治疗后，试验组和对照组大脑后动脉（PCA）血流速度分别为（37.94±5.92）和（31.22±4.48）cm·s^-1,同型半胱氨酸（Hcy）分别为（12.07±2.20）和（16.39±2.80）μmol·L^-1,神经生长因子（NGF）分别为（146.32±12.21）和（130.03±14.22）μg·mL^-1,扣针蛋白5（FBLN-5）分别为（53.81±7.70）和（74.24±8.91）ng·L^-1,基质细胞衍生因子-1（SDF-1）分别为（478.76±51.48）和（676.76±61.33）pg·mL^-1。上述指标，2组比较差异均有统计学意义（均P<0.05）。试验组和对照组的总有效率分别为94.87%和77.50%,差异有统计学意义（P<0.05）。试验组和对照组药物不良反应发生率分别为15.38%和12.50%,差异无统计学意义（P>0.05）。结论 银杏达莫注射液治疗ACI患者疗效确切，可改善患者脑血流，分析与其减轻神经损伤、改善血管内皮功能有关，安全性良好。更多还原

【Abstract】 Objective To observe the application effect, pharmacological mechanism and safety of Ginkgo Damo injection with butylphthalide and sodium chloride injection in the treatment of patients with acute cerebral infarction（ACI）. Methods Patients with ACI were divided into the control group and the treatment group using the random number table method. Both groups received basic treatments. The control group was intravenously given reteplase for injection 10 million U, and the above dose and operation were repeated 0.5 h later, intravenous drip of butylphthalide and sodium chloride injection, 25 mg·time^-1, bid; on the basis of the control group, the treatment group was given Ginkgo damole injection intravenously, 20 mL·time^-1, bid. Both groups were treated for 10 d. The curative effects after treatment, cerebral blood flow velocity,serum levels of nerve injury indexes,vascular endothelial function before and after treatment,and adverse reactions during treatment were compared between the two groups. Results Finally,the control group and the treatment group were 40 and 39 cases. After treatment,the posterior cerebral artery（ PCA） blood speeds of treatment group and control group were（ 37. 94 ± 5. 92） and（ 31. 22 ± 4. 48） cm·s-1,respectively; homocysteine（ Hcy） were（ 12. 07 ± 2. 20） and（ 16. 39 ± 2. 80） μmol·L^-1,respectively; nerve growth factor（ NGF） were（ 146. 32 ± 12. 21）and（ 130. 03 ± 14. 22） μg·m L^-1,respectively; fibulin-5（ FBLN-5） were（ 53. 81 ± 7. 70） and（ 74. 24 ± 8. 91）ng·L^-1,respectively; stromal cells derived factor-1（ SDF-1） were（ 478. 76 ± 51. 48） and（ 676. 76 ± 61. 33）pg·m L^-1,respectively. The differences of the above indicators between the two groups were statistically significant（ all P < 0. 05）. The total effective rates of treatment group and control group were 94. 87% and 77. 50%,respectively,without statistical differences（ P < 0. 05）. The incidences of adverse reactions of treatment group and control group were 15. 38% and 12. 50%,respectively,without significant difference（ P > 0. 05）. Conclusion Ginkgo Damo injection had a definite curative effect in the treatment of patients with ACI,and could improve the cerebral blood flow of patients,which might be related to the reduction of nerve damage and the improvement of vascular endothelial function,and the safety was good.更多还原