【摘要】 以4-氯-3-硝基喹啉为原料，经取代、脱Boc保护、还原、关环和氧化，合成了苯并氮杂靛红化合物（1H-吡咯并[2,3-c]喹啉-1,2（3H）-二酮化合物Ⅵ），总收率为54.23%。利用¹H NMR,¹³C NMR，高效液相色谱和高分辨质谱，对其结构进行了表征。并探讨了化合物Ⅳ、化合物Ⅴ和化合物Ⅵ合成工艺的影响因素。此外还对对中间体Ⅴ和化合物Ⅵ的反应机理进行了探讨。更多还原

【Abstract】 The benzoaza-isatins（1H-pyrrolo[2,3-c]quinoline-1,2（3H）-dione compound Ⅵ） was synthesized from 4-chloro-3-nitroquinoline in overall yield 54.23 % by substitution, remove of protection of Boc, reduction, cyclization and oxidation reaction. The product was characterized by ¹H NMR, ¹³C NMR, High Performance Liquid Chromatography and high resolution mass spectrometry, the effects of reaction the synthesis process of compound Ⅳ, compound Ⅴ and compound Ⅵ were discussed. In addition, the reaction mechanism of intermediate Ⅴ and compound Ⅵ were discussed.更多还原