节点文献

常染色体STR三等位基因型在法医DNA分析中的研究进展

Research Progresses of Tri-Allelic Patterns in Autosomal STR in Forensic DNA Analysis

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 马晓燕孙宏钰黎青

【Author】 MA Xiao-yan;SUN Hong-yu;LI Qing;Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University;Forensic Identification Institute, the Third Affiliated Hospital of Guangzhou Medical University;Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, the Third Affiliated Hospital of Guangzhou Medical University;

【通讯作者】 孙宏钰;黎青;

【机构】 中山大学中山医学院法医学系广州医科大学附属第三医院法医物证司法鉴定所妇产科妇产科研究所实验部广东省产科重大疾病重点实验室广东省妇产疾病临床医学研究中心粤港澳母胎医学高校联合实验室广州医科大学附属第三医院

【摘要】 常染色体STR三等位基因型是法医DNA分析中常见的异常分型现象,给实际检案中证据权重的评估带来困难和不确定性。本文对法医DNA分析中常染色体STR三等位基因型的分类、形成机制、发生率、遗传模式、证据量化评估方法等进行综述,着重基于三等位基因型的不同类型阐述其形成机制及相应的遗传模式,并对三等位基因型的判定及其在亲子鉴定和个体识别中的证据量化评估策略进行讨论,为法医DNA分析中科学化、规范化地解析此类异常分型现象提供参考。

【Abstract】 Tri-allelic pattern in autosomal STR is a common abnormal typing phenomenon in forensic DNA analysis, which brings difficulties and uncertainties to the evaluation of the evidence weight in actual cases. This paper reviews the types, formation mechanism, occurrence frequency, genetic pattern and quantitative evaluation of evidence of the tri-allelic pattern in autosomal STR in forensic DNA analysis. This paper mainly explains the formation mechanism and genetic patterns based on different types of tri-allelic pattern. This paper also discusses the determination of tri-allelic pattern and the quantitative method of evidence evaluation in paternity testing and individual identification. This paper aims to provide references for scientific and standardized analysis of this abnormal typing phenomenon in forensic DNA analysis.

【基金】 国家自然科学基金面上资助项目(81971798);广东省自然科学基金面上资助项目(2019A1515011527);广州市科技计划资助项目(2023A03J0395)
  • 【文献出处】 法医学杂志 ,Journal of Forensic Medicine , 编辑部邮箱 ,2023年03期
  • 【分类号】D919
  • 【下载频次】32
节点文献中: 

本文链接的文献网络图示:

本文的引文网络