【摘要】 放射性皮肤损伤是接受放射治疗的患者常见的并发症，其发病机制复杂，患者个体化差异较大，临床上防治药物疗效良莠不齐，因而积极开发防治放射性皮肤损伤的药物仍十分必要。花椒是中医临床上用于治疗皮肤疾病的常用药，本文研究川陕花椒根皮提取物(ZPE)对人皮肤角质形成细胞HaCaT的辐射防护作用，并初步探讨其机制。研究结果显示，2 mg/mL ZPE对8.0 Gy γ射线照射引起的HaCaT细胞损伤具有防护作用，可减少细胞凋亡和坏死，其作用机制可能与降低细胞炎症因子IL-1β和IL-6的分泌、细胞内ROS水平以及p38和JNK蛋白磷酸化水平有关。本文的研究可为放射性皮肤损伤防治药物的研发提供理论依据。更多还原

【Abstract】 Radiation-induced skin injury is a common complication of patients receiving radiotherapy. Its pathogenesis is complicated and varies greatly with individual patients. Therefore, it is necessary to develop the drugs for prevention and treatment of radiation-induced skin injury. Chinese prickly ash(Zanthoxylum bungeanum) is a common medicine used for skin diseases in traditional Chinese medicine. In this study, the radio-protective effect of the root bark extract of Zanthoxylum piasezkii(ZPE) on HaCaT was investigated and its mechanism was preliminary discussed. The results showed that 2 mg/mL ZPE could protect HaCaT cells from damage induced by 8.0 Gy γ ray irradiation, and could reduce apoptosis and necrosis of HaCaT cells. The mechanism may be related to the reduction of the secretion of IL-1β and IL-6, the level of ROS and the phosphorylation of p38 and JNK proteins. This work provides a theoretical basis for the development of preventive and therapeutic drugs for radiation-induced skin injury.更多还原