【摘要】 目的 分析反复呼吸道感染患儿与炎症因子、免疫功能指标的相关性。方法 选取2019年1月至2021年12月北京市房山区妇幼保健院儿科收治的156例反复呼吸道感染患儿作为观察组，并选取同时间段156名健康体检儿童作为对照组。两组均采集血样行炎症因子（肿瘤坏死因子-α、白细胞介素-6、白细胞介素-8）、免疫功能指标（CD4~+、CD8~+、CD4~+/CD8~+）检查。比较两组检查结果差异，并采用相关性分析反复呼吸道感染与炎症因子、免疫功能指标的相关性。结果 观察组炎症因子指标均高于对照组（P <0.05）。观察组CD4~+、CD4~+/CD8~+低于对照组（P <0.05），而CD8~+高于对照组（P <0.05）。经过相关性分析发现，炎症因子、CD8~+与反复呼吸道感染存在正相关性（P <0.05），而CD4~+、CD4~+/CD8~+与反复呼吸道感染存在负相关性（P <0.05）。结论 反复呼吸道感染患儿与健康儿童比较，存在血清炎症因子水平升高、免疫功能异常的特点。更多还原

【Abstract】 Objective To analyze the correlation between inflammatory factors and immune function indexes in children with recurrent respiratory tract infection. Methods A total of 156 children with recurrent respiratory tract infection admitted to the Department of Pediatrics, Beijing Fangshan District Maternal and Child Health Hospital from January 2019 to December 2021 were selected as the observation group, and 156 healthy children undergoing physical examination during the same period were selected as the control group. Blood samples of both groups were collected for examination of inflammatory factors(tumor necrosis factor-α, interleukin-6, interleukin-8) and immune function indicators(CD4~+, CD8~+, CD4~+/CD8~+). The differences of examination results between the two groups were compared,and correlation between recurrent respiratory tract infection and inflammatory factors and immune function indexes was analyzed by correlation analysis. Results The indexes of inflammatory factors in observation group were higher than those in control group(P < 0.05). CD4~+ and CD4~+/CD8~+ in the observation group were lower than those in the control group(P < 0.05), while CD8~+ was higher than that in the control group(P < 0.05). The correlation analysis showed that inflammatory factors and CD8~+ were positively correlated with recurrent respiratory tract infection(P < 0.05), while CD4~+ and CD4~+/CD8~+ were negatively correlated with recurrent respiratory tract infection(P < 0.05). Conclusion Compared with healthy children, children with recurrent respiratory tract infection have the characteristics of elevated serum inflammatory factors and abnormal immune function.更多还原