【摘要】 目的 了解宜昌市水源水中抗生素分布特征及其对人体的健康风险，为饮用水中抗生素等新型污染防治提供科学依据；方法 采用固相萃取技术(SPE)富集，超高效液相色谱-串联质谱法(UPLC-MS/MS)检测分析宜昌市主要饮用水源水中磺胺类、四环素类、氯霉素类、喹诺酮类、β-内酰胺类等五类抗生素含量水平，并对其进行人体健康风险评价；结果 宜昌市水源水中五类抗生素均有检出，检出率为6.25%～81.25%,β-内酰胺类抗生素总检出率最高，诺氟沙星的检出浓度最高为213.9ng/L。对检出的11种抗生素进行健康风险评价显示这几种抗生素不会对人体产生明显的健康危害，但存在年龄越小风险熵值(RQ_H)越大的趋势；结论 宜昌市水源水中抗生素分布水平不会对人体产生明显的健康危害。更多还原

【Abstract】 Objective To investigate the distribution characteristics of antibiotics in source water and their health risks to human body in Yichang City, and to provide a scientific basis for the prevention and control of new types of pollution such as antibiotics in drinking water. Methods Solid phase extraction(SPE) was used for enrichment, and ultra-high performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS) was used to detect and analyze the content of five types of antibiotics including sulfonamides, tetracyclines, chloramphenicol, quinolones and β-lactams in the main drinking water sources of Yichang City.The human health risk assessment of these antibiotics was conducted. Results All five types of antibiotics were detected in the source water of Yichang City, and the detection rate was 6.25% to 81.25%.The total detection rate of β-lactam antibiotics was the highest, and the highest detection concentration of norfloxacin was 213.9 ng/L.The health risk assessment of 11 antibiotics detected in the source water showed that these antibiotics would not cause obvious health harm to human body, but the risk entropy(RQ_H) tended to increase with the younger age. Conclusion The distribution level of antibiotics in source water of Yichang City will not cause obvious health harm to human body.更多还原