【摘要】 目的 了解深圳市2020—2021两年内室内灰尘中氟虫腈(FP)及其代谢产物的残留水平，并分析其随着时间变化的特征。方法 在2020—2021年期间，采集来自深圳市的室内灰尘样品，共193份(2020年，n=87;2021年，n=106)。应用超高效液相色谱-串联质谱法(Ultra-performance liquid chromatography-tandem mass spectrometry, UPLC-MS/MS)检测灰尘样品中FP及其主要代谢产物的实际浓度及加和质量浓度(ΣFPMs),应用Wilcoxon检验分析样品中FPMs的时间分布差异。结果 2020—2021年深圳市室内ΣFPMs的浓度范围为0.51～4 415ng/g(中位数18.8ng/g),其中FP、FP-SFO和FP-SFI是主要检测到的目标化合物，检出率分别为90.60%,86.20%和75.40%,其余代谢物检出率较低(≤44.3%)。深圳市2020—2021年间春夏季与秋冬季样本中ΣFPMs浓度无显著性差异(2.38 vs 2.84ng/g,P>0.05),但在深圳市2021年灰尘样品中FP-SFI和ΣFPMs浓度与2020年相比具有显著性的上升趋势(1.02 vs 1.89,17.8 vs 20.1ng/g,P<0.05)。结论 2020—2021年深圳市室内灰尘中FPMs浓度检出水平较高且逐年呈现上升趋势，无明显季节差异，室内灰尘中FPMs残留水平是否对人群健康构成风险，需进一步研究。更多还原

【Abstract】 Objective To explore the residual level of FPMs in indoor dust samples in Shenzhen from 2020 and 2021,and to analyze its temporal distribution characteristics. Methods In the present study, indoor dust samples(n=193) from residential buildings in Shenzhen.were collected to analyze the temporal variation characteristics of FPMs.Ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was applied to determine the concentrations of FP and its four major metabolites(fipronil-sulfone, fipronil-sulfide, fipronil-desulfinyl, and fipronil-amide; abbreviated as FP-SFO,FP-SFI,FP-DES,and FP-AM) in the samples.The sum of the concentrations of FP and its four metabolites was represented as additive mass concentration(ΣFPMs).Additionaly, Wilcoxon test was performed to determine the temporal distribution differences of FPMs′ concentrations. Results From 2020 to 2021,the concentration of ΣFPMs for the in door dust samples in Shenzhen ranged from 0.51 to 4 415 ng/g(median: 18.8ng/g).FP,FP-SFO AND FP-SFI were the major target analytes in the sample with detection rates of 90.60%,86.20% and 75.40%,respectively.The detection rates of other metabolites were low(≤44.3%).Analysis of the temporal variation trend of FPMs′ concentrations showed that there was no significant difference in the levels of ΣFPMs between warm season(spring and summer)and cold season(autumn and winter)in the indoor dust samples from 2020 to 2021(2.38 vs 2.84ng/g, P>0.05).However, the concentrations of FP-SFI and ΣFPMs in the indoor dust samples collected from 2021 showed an significantly increasing trend compared with 2020(1.02 vs 1.89,17.80 vs 20.10 ng/g, P<0.05). Conclusion From 2020 to 2021,the detection level of FPMs in indoor dust in Shenzhen is relatively high and shows an upward trend, with no obvious seasonal difference.However, whether the residual level of FPMs in indoor dust poses a risk to human health needs further study.更多还原