【摘要】 目的 分析蚌埠地区无偿献血者梅毒螺旋体颗粒凝集试验(TPPA)阳性人群特征，为招募低危献血者提供数据支持。方法 采用梅毒螺旋体颗粒凝集实验(TPPA)对蚌埠地区154 225例献血者标本中检出的250例TP-ELISA阳性标本进行确认检测，统计献血者信息，分析TPPA阳性献血者人群特征。结果 本研究共确认TPPA阳性标本107例，男性TPPA阳性率(0.71‰,56/79 047)与女性(0.68‰,51/75 178)比例接近1∶1,差异未见统计学意义(P>0.05)。35～44岁组TPPA阳性率(0.93‰,34/36 547)和45～60岁组(1.12‰,45/40 102)均显著高于18～34岁组(0.36‰,28/77 576),差异有统计学意义(P均<0.05)。初中及以下组TPPA阳性率(0.91‰,69/75 841)和高中及中职组阳性率(0.97‰,17/17 535)均显著高于大专及以上组(0.35‰,21/60 799),差异有统计学意义(P均<0.05)。首次献血组TPPA阳性率(1.48‰,86/58 259)显著高于重复献血组(0.22‰,21/95 966),差异有统计学意义(P均<0.05)。市区固定采血点TPPA阳性率(0.78‰,35/45 127)和县区固定采血点阳性率(0.81‰,27/33 368)均高于流动采血车(0.59‰,45/75730),差异未见统计学意义(P>0.05)。结论 蚌埠地区TPPA阳性的无偿献血者人群尚不存在明显的性别和区域分布的差异性，但是年龄在35岁以上，高中、中职及以下文化层度的首次献血人群，可能会存在较高的梅毒献血传播的风险。此外，固定采血点工作人员应继续提升重复献血者人群数量，从低危无偿献血者中采集安全的血液。更多还原

【Abstract】 Objective To analyze the characteristics of Treponema pallidum particle agglutination(TPPA)positive voluntary blood donors in Bengbu area, and to provide data support for recruiting low-risk blood donors. Methods Treponema pallidum particle agglutination(TPPA) was used to confirm 250 TP-ELISA positive samples from 154225 blood donors in Bengbu area. The information of blood donors was analyzed, and the characteristics of TPPA positive blood donors were analyzed. Results A total of 107 TPPA positive specimens were confirmed in this study. The positive rate of TPPA in males(0.71‰, 56/79047) and females(0.68‰, 51/75178) was close to 1∶1, there was no significant difference(P>0.05). The positive rates of TPPA in 35-44 years old group(0.93‰, 34/36547) and 45-60 years old group(1.12‰, 45/40102) were significantly higher than those in 18-34 years old group(0.36‰, 28/77576), there were significant differences(P<0.05). The positive rate of TPPA in junior high school and below group(0.91‰, 69/75841) and senior secondary and secondary vocational sections(0.97‰, 17/17535) were significantly higher than those in junior college and above group(0.35‰, 21/60799), there were significant differences(P<0.05). The positive rate of TPPA in the first time blood donation group(1.48‰, 86/58259) was significantly higher than that in the repeated blood donation group(0.22‰, 21/95966), there were significant differences(P<0.05). The positive rate of TPPA in urban fixed blood collection sites(0.78‰, 35/45127) and county fixed blood collection sites(0.81‰, 27/33368) was higher than that in mobile blood collection vehicles(0.59‰, 45/75730), there was no significant difference(P>0.05). Conclusions There is no obvious difference in gender or regional distribution among TPPA-positive voluntary blood donors in Bengbu area, but the first time blood donors who are over 35 years old, senior secondary, secondary vocational sections and lower cultural levels may have a higher risk of syphilis blood donation transmission. In addition, the staff of fixed blood collection sites should continue to increase the number of repeated blood donors and collect safe blood from low-risk voluntary blood donors.更多还原