【摘要】 家蚕丝素蛋白被报道具有一定的解酒功能，但是相关机理仍不明确。本实验通过构建小鼠急性酒精性肝损伤模型来研究丝素蛋白对其肝损伤的防护作用，通过肠道微生物来探讨丝素蛋白发挥功效的机制。结果显示，丝素蛋白的干预可以降低酒精引起的血清中谷丙转氨酶、谷草转氨酶和甘油三酯的升高，使其恢复到正常水平，并且能够显著改善受损肝脏组织的病理学变化。有关肠道微生物的分析则表明，家蚕丝素蛋白可以恢复小鼠肠道菌群的α多样性和β多样性，使厚壁菌门/拟杆菌门的比值趋于健康水平，从而有效改善了酒精引起的肠道微生物失衡的状况。结果表明，家蚕丝素蛋白可以通过改善肠道菌群来防护小鼠的急性酒精性肝损伤。更多还原

【Abstract】 Bombyx mori silk fibroin(SF) has been reported to play a role in dispelling the effects of alcohol. However, the related mechanism has been not addressed. In this study, we constructed a mice model of acute alcoholic liver injury to investigate the protective effects of silk fibroin, and tried to answer why SF could dispel the effects of alcohol in terms of gut microbiota. The results showed that the intervention of silk fibroin could not only reduce the indexes of glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase and triglyceride to normal levels, but also improve the pathological changes of the injured liver tissue. According to the analysis of gut microbiota, Bombyx mori SF could recover the α-diversity and β-diversity of gut microbiota and meanwhile modulate the ratio of Firmicutes/Bacteroides to a healthy level, resulting in an effective improvement of the dysbiosis of gut microbiota. Therefore, we believed that Bombyx mori SF could be used to prevent acute alcoholic liver injury in mice by modulating the gut microbiota.更多还原