【摘要】 目的 探讨女性生殖系统血管肌纤维母细胞瘤临床病理特征。方法 选取该院2010年1月至2021年12月收治的7例女性生殖系统血管肌纤维母细胞瘤病例，对其临床和病理资料进行回顾性分析，并复习文献。结果 患者发病年龄为36～55岁，中位发病年龄46岁；病程6～36个月，平均14个月。主要临床表现为外阴、阴道及臀部发现无痛性肿物，其中4例位于大阴唇(左侧2例，右侧2例),1例位于左侧阴阜，1例位于宫颈，1例位于右侧臀部。肿物最大直径1～8 cm,平均4 cm。5例呈实性，2例呈囊性，肿物均可活动，边界清楚。术前检查，患者肿瘤标志物水平均位于正常范围。超声检查均提示肿物异常回声，3例考虑囊肿，1例考虑血管瘤，1例考虑肿大淋巴结，1例考虑肌瘤，1例考虑脂肪瘤。所有病例均行单纯肿物切除术，术后病理均诊断为血管肌纤维母细胞瘤，2例部分区域兼类似侵袭性血管黏液瘤改变，1例部分区域细胞伴轻度异型。术后随访47～148个月，患者均存活，无复发。结论 女性生殖系统血管肌纤维母细胞瘤是一种罕见的良性间质细胞肿瘤，需术后病理确诊。更多还原

【Abstract】 Objective To investigate the clinicopathological features of angiomyofibroblastoma of the female reproductive system.Methods Seven cases of angiomyofibroblastoma of the female reproductive system admitted to the hospital from January 2010 to December 2021 were selected, and their clinical and pathological data were retrospectively analyzed, and the literature was reviewed.Results The patients were 36-55 years old, with a median age of 46 years; the disease course was 6-36 months, with an average disease course of 14 months.The clinical manifestations were mainly painless lumps found in the vulva, vagina and buttocks.Among them, 4 cases were located in the labia majora(2 cases on the left side and 2 cases on the right side),1 case was located in the left mons pubis, 1 case was located in the cervix, and 1 case was located in the right buttock.Tumors ranged from 1 to 8 cm in maximum diameter, with an average diameter of 4 cm.5 cases were solid and 2 cases were cystic.The masses were movable with clear boundaries.In the preoperative examination, the levels of tumor markers in the patients were within the normal range.Ultrasonography showed abnormal echoes of the mass, 3 cases considered cyst, 1 case considered hemangioma, 1 case considered enlarged lymph node, 1 case considered fibroid, and 1 case considered lipoma.All cases underwent simple tumor resection, and the postoperative pathological diagnosis was angiomyofibroblastic tumor.2 cases had partial area and similar aggressive angiomyxoma changes, and 1 case had partial area cells with mild atypia.The patients were followed up for 47-148 months, and all patients survived without recurrence.Conclusion Angiomyofibroblastoma is a rare indolent benign mesenchymal tumor.Postoperative pathology is needed to confirm the diagnosis.更多还原