【摘要】 目的 探讨糖尿病患者凝血四项与血脂指标检验的临床应用价值。方法 选择2020年1月—2023年1月至平邑县人民医院就诊的200例糖尿病患者作为研究组，另外选择同时间段200名健康体检者作为对照组。检测两组受检者凝血四项[包括凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（Fib）]和血脂指标[包括三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）]，比较两组上述指标水平差异并分析检验的准确性。结果 研究组的PT、APTT、TT水平均明显低于对照组，Fib水平明显高于对照组[PT(s):10.72±0.56比12.50±0.71,APTT(s):28.36±3.02比34.52±3.52,TT(s):13.35±1.20比17.24±1.33,Fib(g/L):4.65±0.68比3.35±0.58，均P<0.05]。研究组的TG、LDL-C、TC水平均明显高于对照组，HDL-C水平明显低于对照组[TG(mmol/L):3.36±0.52比1.60±0.39,LDL-C(mmol/L):3.25±0.62比1.25±0.38,TC(mmol/L):5.52±0.92比4.52±0.75,HDL-C(mmol/L):1.20±0.33比1.70±0.42，均P<0.05]。凝血四项与血脂指标联合检测的准确度明显高于两项检测单独应用（98.00%比85.00%、86.00%，均P<0.05）。结论 与健康人群比较，糖尿病患者的凝血四项和血脂指标水平均发生异常改变，加强凝血四项及血脂指标检验，有助于提高检验准确性，从而指导疾病诊疗，临床应用价值显著。更多还原

【Abstract】 Objective To investigate the application value of blood coagulation four items and blood lipid indicators detection in diabetic patients. Methods A total of 200 patients with diabetes mellitus in Pingyi County People’s Hospital from January 2020 to January 2023 were selected as research group, and 200 healthy subjects during the same period were selected as control group. Four items of blood coagulation [including prothrombin time(PT), activated partial thromboplastin time(APTT), thrombin time(TT) and fibrinogen(Fib)] and blood lipid indicators [including triglycerides(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C)] in two groups were detected, the differences of the above indicators between the two groups were compared, and the accuracy of the test was analyzed. Results The levels of PT,APTT and TT in research group were significantly lower than those in control group, and the level of Fib was significantly higher than that in control group [PT(s): 10.72±0.56 vs. 12.50±0.71, APTT(s): 28.36±3.02 vs.34.52±3.52, TT(s): 13.35±1.20 vs. 17.24±1.33, Fib(g/L): 4.65±0.68 vs. 3.35±0.58, all P < 0.05]. The levels of TG, LDL-C and TC in research group were significantly higher than those in control group, and the level of HDL-C was significantly lower than that in control group [TG(mmol/L): 3.36±0.52 vs. 1.60±0.39, LDL-C(mmol/L):3.25±0.62 vs. 1.25±0.38, TC(mmol/L): 5.52±0.92 vs. 4.52±0.75, HDL-C(mmol/L): 1.20±0.33 vs. 1.70±0.42,all P < 0.05]. The accuracy of blood coagulation four items combined with blood lipid indicators test was significantly higher than those of two methods alone(98.00% vs. 85.00%, 86.00%, both P < 0.05). Conclusions Compared with healthy people, the levels of blood coagulation four items and blood lipid indicators in diabetic patients have abnormal changes. Strengthening the test of blood coagulation four items and blood lipid indexes is helpful to improve the accuracy, so as to guide the diagnosis and treatment of the disease, with significant clinical application value.更多还原