【摘要】 目的 基于合成MRI(synthetic MRI, sMRI)技术及基于体素的形态学测量(voxel-based morphometry, VBM)全脑分区的方法，探讨帕金森病(Parkinson’s disease, PD)早期阶段的脑体积及弛豫值改变，并为该病的早期诊断提供影像学依据。材料与方法 本研究前瞻性纳入22例早期PD(early-stage PD, ESP)患者为ESP组，25例性别及年龄匹配的健康对照(healthy controls, HC)为HC组。所有研究对象应用GE 3.0 T MR采集常规序列、3D T1WI、sMRI的定量图谱磁共振成像(magnetic resonance imaging compilation, MAGiC)扫描，并进行简易精神状态检查(Mini-Mental State Examination,MMSE)量表评分。使用MATLAB软件SPM 12数据处理包对所有数据进行VBM全脑分区，得到不同皮质和皮质下区域的全脑和各脑区灰质体积(gray matter volume, GMV)、白质体积(white matter volume, WMV)及脑区弛豫值。比较ESP组与HC组之间的体积特征和脑区域弛豫值差异，对ESP组各脑区体积以及T1、T2和质子密度(proton density, PrD)值与MMSE评分做Spearman相关分析。对相关性分析结果差异最明显脑区作ROC曲线，且对该脑区作各序列弛豫值联合诊断。结果 脑区体积与临床量表有相关性者较多(P<0.05)。部分脑区弛豫值在HC组及ESP组之间有差异，但右侧丘脑的弛豫值差异性及与MMSE评分之间相关性存在于全部各个序列，故应用右侧丘脑的各序列弛豫值做ROC曲线诊断，且应用右侧丘脑在T1及T2各序列弛豫值作联合诊断，AUC为0.822(0.697-0.911)。结论 本研究的结果表明，ESP患者具有右侧丘脑脑体积和脑区弛豫值变化。该研究认为，通过右侧丘脑在sMRI的各序列弛豫值可对PD作出早期诊断。更多还原

【Abstract】 Objective:To explore the changes of brain volume and relaxation value in the early stage of early stage of Parkinson’s disease(ESP) based on synthetic MRI(sMRI) technology and voxel-based morphometry(VBM) whole brain partitioning method,and provide imaging basis for the early diagnosis of this disease.Materials and Methods:In this study,22 patients with ESP were prospectively included in the ESP group,and 25 sex-and age-matched healthy control(HC) in the HC group.All subjects were scanned using GE 3.0 T MR to acquire conventional sequence,3D T1WI and quantitative magnetic resonance imaging(MAGiC) scans,and performed Minimum Mental State Examination(MMSE) scoring.The MATLAB software SPM 12 data processing package was used to VBM whole brain partition of all data,and the gray matter volume(GMV),white matter volume(WMV) and brain region relaxation value of the whole brain and each brain region in different cortical and subcortical regions were obtained.The volume characteristics and brain region relaxation values between ESP group and HC group were compared,and the volume of brain regions,T1,T2 and proton density(PrD) values and MMSE scores were analyzed in the case group.The ROC curve was made for the brain region with the most obvious difference in correlation analysis results,and the relaxation values of each sequence were jointly diagnosed in this brain region.Results:There were more cases in which the volume of brain regions correlated with clinical scales(P<0.05).There were differences in the relaxation values of some brain regions between the HC group and ESP,but the difference in the relaxation values of the right thalamus and the correlation with the MMSE score existed in all sequences,so the relaxation values of each sequence of the right thalamus were used for ROC diagnosis,and the relaxation values of the right thalamus in T1 and T2 sequences were used for joint diagnosis,and the AUC was 0.822(0.697-0.911).Conclusions:The results of this study showed that ESP patients had changes in right thalamic volume and brain region relaxation values.In this study,it is believed that the relaxation values of the right thalamus in the various sequences of sMRI can make an early diagnosis of PD.更多还原