【摘要】 从旱莲草中分离到7个单体化合物，经波谱数据分析，鉴定为旱莲皂苷eclalbasaponinsⅠ～Ⅵ(缩写为E-Ⅰ～E-Ⅵ)和β-香树素，其中E-Ⅰ～E-Ⅴ有溶血活性，活性强弱依次为E-Ⅱ>E-Ⅳ>E-Ⅴ>E-Ⅰ>E-Ⅲ.构效关系分析结果表明：C-28位的游离羧基对旱莲皂苷的溶血活性强弱至关重要，C-3位葡萄糖基的数量或硫酸酯化对其溶血活性也有影响.更多还原

【Abstract】 Seven compounds are isolated from Eclipta alba.These compounds are identified as eclalbasaponins Ⅰ～Ⅵ(abbreviated for E-Ⅰ～E-Ⅵ) and β-amyrin based on the spectral data.Five compounds, namely E-Ⅰ～E-Ⅴ,show hemolytic activities that the decreasing order is E-Ⅱ>E-Ⅳ>E-Ⅴ>E-Ⅰ>E-Ⅲ.Analysis of structure-activity relationships indicates that free carboxyl at C-28 plays a crucial role in the hemolytic activities of eclalbasaponins.Both the amount and the sulfation of the glucosyl at C-3 also influence the hemolytic activities of eclalbasaponins.更多还原