【摘要】 目的 探讨舍曲林对创伤后应激障碍(PTSD)大鼠海马炎症反应的保护作用及其可能机制。方法 将大鼠随机分为正常对照组、PTSD模型组及PTSD+舍曲林组，评估三组大鼠的行为学变化，观察海马形态变化，并检测血清中TNF-α和IL-1β含量及海马组织中高流动性组蛋白B1(HMGB1)、TNF-α及IL-1β的表达。结果 与正常对照组比较，PTSD模型组大鼠焦虑反应明显增强，海马结构紊乱，且凋亡神经元显著增加；其血清TNF-α、IL-1β水平，及海马组织中HMGB1、TNF-α和IL-1β蛋白表达均明显上调(P<0.05)。给予舍曲林治疗后，PTSD大鼠焦虑反应明显减轻，海马结构改善，凋亡神经元减少；其血清TNF-α、IL-1β水平及海马中HMGB1、TNF-α及IL-1β蛋白表达均显著降低(P<0.05)。结论 舍曲林可能通过降低炎性反应，抑制海马神经元凋亡，减轻神经组织损伤，有效改善大鼠的焦虑反应，从而对PTSD大鼠发挥保护作用。更多还原

【Abstract】 Objective To explore the protective effect of sertraline on hippocampal inflammation in rats with post-traumatic stress disorder(PTSD) and its possible mechanism.Methods Rats were randomly divided into the normal control group, the PTSD model group, and the PTSD model +sertraline treatment group. The behavioral changes of the 3 groups of rats were evaluated. The morphological changes of hippocampus of rats were observed. The contents of TNF-α and IL-1β in serum, and the expression of high mobility group box1(HMGB1), TNF-α and IL-1βin hippocampus were detected.Results Compared with the normal control group, the anxiety response of rats in the PTSD model groupwas significantly enhanced, the hippocampal structure was more disordered, and the apoptotic hippocampal neurons increased significantly.The levels of TNF-αand IL-1β in serum ofthe PTSD model group significantly increased, and the expression of HMGB1, TNF-α and IL-1β in hippocampus were significantly up-regulated(P<0.05).After treatment with sertraline, the anxiety response of PTSD rats significantly reduced, the hippocampal structure improved, and apoptotic neurons reduced. The levels of TNF-α and IL-1β in serum of PTSD rats markedly reduced, and the expression of HMGB1, TNF-α and IL-1β in hippocampus obviously decreased(P<0.05).Conclusion Sertraline can play a protective role in rats with PTSD by reducing inflammatory response, inhibiting the apoptosis of hippocampal neurons, alleviatingthe damage of nervous tissue and improving the anxiety response effectively.更多还原