【摘要】 目的:通过系统评价与Meta分析方法研究结缔组织病相关间质性肺病(CTD-ILD)患者血清涎液化糖链抗原-6(KL-6)与肺功能、实验室指标的相关性。方法:系统检索知网、万方、维普、Pub Med、Cochrane Library及Web of Science数据库,从建库至2021年9月18日关于CTD-ILD患者KL-6与肺功能、实验室指标相关性的研究,对符合纳入标准的文献采用R 4.02软件进行Meta分析。结果:共纳入25个研究,包含1 846名CTD-ILD患者。Meta分析结果显示:肺功能指标与血清KL-6有不同程度的负相关性,相关系数-0.619～-0.272;乳酸脱氢酶与血清KL-6有相关性,相关系数为0.383,其余实验室指标与血清KL-6无相关性(P>0.05)或弱相关性(r=-0.195～0.091)。结论:血清KL-6能够反映出CTD-ILD患者肺功能与炎症的严重程度,可作为CTD-ILD患者早期病情判断与临床决策的参考指标。更多还原

【Abstract】 Objective: To investigate the correlation between Krebs von den lungen-6(KL-6) and lung function or laboratory indicators in connective tissue disease-associated interstitial lung diseases(CTD-ILD) by systematic review and meta-analysis. Methods: The literature about correlation between KL-6 and lung function or laboratory index in CTD-ILD patients were retrieved from CNKI, Wanfang, VIP, Pub Med, Cochrane Library, and Web of Science databases from the establishment to September 18, 2021. The metaanalysis was performed using R 4.02 software. Results: There were 25 studies enrolled, including 1 846 CTDILD patients. The results of meta-analysis suggested that the indicators of lung function were negatively correlated with serum KL-6, with correlation coefficient from-0.619 to-0.272. Lactate dehydrogenase(LDH) was positively associated with serum KL-6, with the correlation coefficient of 0.383. There was no or weak correlation between other laboratory indexes and serum KL-6(P >0.05, or r=-0.195 to 0.091).Conclusion: Serum KL-6 can reflect the severity of pulmonary function and inflammation in patients with CTD-ILD, which can be used as a reference index for early diagnosis and clinical decision of CTD-ILD.更多还原