【摘要】 目的 对全血献血者人群中抑郁流行病学情况进行调查并作相关因素分析，在此基础上构建快速有效的献血者人群抑郁筛查模型。方法 2020年5～8月，在本中心各街头献血点捐献全血的献血者共计13 015名，指导其完成包含社会人口学信息及抑郁筛查量表(PHQ-9)的匿名电子问卷调查，PHQ-9量表评分10分及以上判定为筛查抑郁。用SPSS 26.0做Logistic回归分析抑郁相关因素并建立2级决策树，父节点/子节点中的最小样本数为30/10,进行10折交叉验证，剪枝PHQ-9的题项，形成献血者抑郁的快速筛查模型。结果 13 015名街头全血献血者中，364(2.80%)人的PHQ-9得分≥10分。年龄18～29岁(P<0.05)、未婚(P<0.05)、家庭人均年收入低于5万元的献血者(P<0.05)更易出现抑郁。决策树分析发现，81.96%PHQ-9得分“<10分”及3.85%“≥10分”的献血者被包含在PHQ-9的第6、2和4题项形成的两个终端节点中。由此3个题项构建出一个快速筛查模型，经10倍交叉法验证，该模型的误判率仅为1.70%。结论 广州地区全血献血者人群中基于PHQ-9筛查的抑郁率为2.80%(95%CI:2.52%～3.09%),献血次数与初筛抑郁不相关。基于PHQ-9的第6、2和4题项可建立1个快速准确的献血者抑郁快速筛查模型。更多还原

【Abstract】 Objective To investigate the prevalence of depression in blood donors and analyze the related factors, so as to develop a rapid depression screening model for blood donors. Methods A total of 13 015 street whole blood donors in Guangzhou Blood Center during May to August, 2020 filled in an anonymous e-questionnaire, including social demography information and the Patient Health Questionnaire-9 before donation. The cut-off value for detecting depression was 10. Logistic regression by SPSS 26.0 was used to analyze depression related factors. 2-level decision tree with 30/10 as the minimum number of cases in parent/child node, 10-fold cross validation was used to cut items of PHQ-9 to form the depression screening model. Results 364 out of 13 015(2.80%) street whole blood donors reported a score ≥10. Donors with 18-29 years old(P<0.05), unmarried(P<0.05), less than 50 000 RMB household income per year(P<0.05) were more prone to depression. 81.96% donors in “<10 scores” group, while 3.85% donors in “≥10 scores” group were in two terminal nodes formed by Item-6, 2 and 4 of PHQ-9. After verification by the 10 fold crossover method, the estimated misclassification risk of the model was 1.7%. Conclusion The screening prevalence of depression based on PHQ-9 in Guangzhou blood donors was 2.8%(95%CI:2.52%-3.09%). Donation frequency was not related to depression. A rapid and efficient depression screening model for blood donors based on item-6, 2 and 4 of PHQ-9 was developed.更多还原