【摘要】 目的 探讨真实世界中药汤药辅助治疗对原发性肝癌（primary liver cancer, PLC）患者生存结局的影响。方法选取2017—2022年湖北省中医院连续住院的PLC患者124例，根据从入组到末次随访时患者是否累计使用中药汤药≥1个月分为暴露组（79例）和非暴露组（45例）。通过医院信息系统、电子病历及人工回访收集信息，主要终点为总生存期（overall survival, OS），次要终点为无进展生存期（progression free survival, PFS），采用Kaplan-Meier法评估总生存率，采用多因素Cox回归方程分析暴露因素对生存结局的影响。结果 124例PLC患者中，男110例，女14例，年龄24～80岁，平均（60.8±11.9）岁。Kaplan-Meier生存分析结果显示，暴露组中位OS及中位PFS高于非暴露组（28.14个月比10.89个月，11.62个月比5.56个月），差异均有统计学意义（P <0.05）。多因素Cox回归结果显示，中药汤药暴露是OS(HR=1.434,95%CI:1.248～1.762,P=0.004)及PFS(HR=1.509,95%CI:1.312～1.832,P=0.007)的独立保护因素。结论中药汤药可作为一种有效的辅助治疗策略，可以提高PLC患者的生存率，延长OS及PFS，改善预后。更多还原

【Abstract】 Objective To explore the influence of real-world traditional Chinese medicine decoction on the survival outcomes of patients with primary liver cancer(PLC) in real-world. Methods A total of 124 consecutive inpatients with PLC in Hubei Provincial Hospital of traditional Chinese medicine from 2017 to 2022 were selected, and were divided into exposure group(79 cases) and non-exposure group(45 cases) according to whether the patients used traditional Chinese medicine decoction for more than one month from the time of enrollment to the last follow-up. Information was collected through the hospital information system, electronic medical records and manual follow-up. The primary endpoint was overall survival(OS), and the secondary endpoint was progression free survival(PFS). Overall survival rate was evaluated by Kaplan-Meier, and the influence of exposure factors on the survival outcome was analyzed by multivariate Cox regression equation. Results Among the 124 PLC patients, there were 110 males and 14 females, aged from 24 to 80 years, with an average of(60.8 ± 11.9) years. Kaplan-Meier survival analysis showed that the median OS and PFS in the exposure group were higher than those in the non-exposure group(28.14 months vs. 10.89 months, 11.62 months vs. 5.56 months), and the differences were statistically significant(P < 0.05). Multivariate Cox regression showed that the exposure of traditional Chinese medicine decoction was an independent protective factor for OS(HR = 1.434, 95%CI: 1.248-1.762, P = 0.004) and PFS(HR = 1.509, 95%CI: 1.312-1.832, P = 0.007). Conclusions Traditional Chinese medicine decoction can be used as an effective adjunctive treatment strategy, which can improve the survival rates of PLC patients, and extending OS and PFS and improve the prognosis.更多还原