【摘要】 目的：探讨人舌鳞状细胞癌(TSCC)组织中胞质多聚腺苷化元件结合蛋白3(CPEB3)的表达及其临床意义。方法：通过UALCAN在线分析CPEB3在头颈部鳞状细胞癌(HNSC)组织中的差异表达及其与临床特征的相关性，免疫组织化学法检测CPEB3在TSCC和癌旁组织中的表达，分析CPEB3表达水平与TSCC病人病理特征间的相关性。结果：生物信息学分析结果显示，CPEB3在HNSC组织中的表达量明显低于正常组织(P<0.01)。与正常组织相比，CPEB3在不同分期和分化程度的HNSC病人中表达量降低(P<0.05);CPEB3低表达的HNSC病人的3年生存率低于CPEB3高表达的病人(P<0.05)。与癌旁组织相比，CPEB3在TSCC组织中低表达(P<0.01);CPEB3的表达与TSCC病人的性别和年龄无明显相关性(P>0.05),而与TNM分期、病理分级和淋巴结转移有相关性(P<0.05～P<0.01)。结论：CPEB3在TSCC中低表达，并与TNM分期、分化程度和淋巴结转移相关，CPEB3可能为TSCC诊断和治疗的潜在生物标志物。更多还原

【Abstract】 Objective:To investigate the expression and clinical significance of cytoplasmic polyadenylation element binding protein 3(CPEB3) in human tongue squamous cell carcinoma(TSCC) tissue.Methods:The differential expression of CPEB3 and its correlation with clinical features in head and neck squamous-cell carcinoma(HNSC) tissue were analyzed online by UALCAN,the expression of CPEB3 in TSCC and adjacent cancer tissues was examined by immunohistochemistry, and the correlation between the expression level of CPEB3 and pathological characteristics of TSCC patients was analyzed.Results:The results of bioinformatics analysis showed that the expression level of CPEB3 in HNSC tissue was significantly lower than that in normal tissue(P<0.01).Compared with normal tissue, the expression level of CPEB3 decreased in HNSC patients with different stages and degrees of differentiation(P<0.05).The 3-year survival rate of HNSC patients with low CPEB3 expression was lower than that of patients with high CPEB3 expression(P<0.05).Compared with adjacent cancer tissue, CPEB3 was low-expressed in TSCC tissue(P<0.01).The expression of CPEB3 was not significantly correlated with the gender and age of TSCC patients(P>0.05),but was correlated with TNM stage, pathological grade, and lymph node metastasis(P<0.05 to P<0.01).Conclusions:CPEB3 is low expressed in TSCC and correlated with TNM stage, degree of differentiation, and lymph node metastasis.CPEB3 may be a potential biomarker for the diagnosis and treatment of TSCC.更多还原