【摘要】 目的 探讨红细胞沉降率（ESR）、血清白蛋白（ALB）、dickkopf WNT信号通路抑制剂1(DKK1)在多发性骨髓瘤（MM）中的表达及对预后的预测价值。方法 选取106例MM患者作为MM组，另选取同期100例健康体检者作为健康对照组，比较两组受试者ESR、ALB、DKK1水平。根据预后情况，将MM患者分为死亡组（n=14）和生存组（n=92），比较两组患者ESR、ALB、DKK1水平。采用受试者工作特征（ROC）曲线分析ESR、ALB、DKK1单独及联合检测对MM的诊断价值及对MM患者预后的预测价值。结果 MM组患者ESR、DKK1均明显高于健康对照组，ALB明显低于健康对照组，差异均有统计学意义（P<0.01）。死亡组患者ESR、DKK1均明显高于生存组，ALB明显低于生存组，差异均有统计学意义（P<0.01）。ROC曲线显示，ESR、ALB、DKK1联合检测对MM的诊断价值及对MM患者预后的预测价值均高于任一指标单独检测。结论 ESR、DKK1在MM中高表达，ALB在MM中低表达，ESR、ALB、DKK1联合检测对MM具有较好的诊断效能，可作为MM发生发展及预后判断的辅助参考指标，值得临床推广应用。更多还原

【Abstract】 Objective To investigate the expression of erythrocyte sedimentation rate(ESR), serum albumin(ALB),and dickkopf WNT signaling pathway inhibitor 1(DKK1) in multiple myeloma(MM) and their predictive value for prognosis. Method A total of 106 MM patients were selected as the MM group, and 100 healthy subjects undergoing physical examination during the same period were selected as the healthy control group, the ESR, ALB, and DKK1 levels of the two groups were compared. MM patients were divided into the death group(n=14) and the survival group(n=92) according to prognosis, the ESR, ALB, and DKK1 levels of the two groups were compared. The receiver operating characteristic(ROC) curve was used to analyze the diagnostic value of ESR, ALB, and DKK1 alone and combined detection for MM and the predictive value for the prognosis of MM patients. Result The ESR and DKK1 of the MM group were significantly higher than those of the healthy control group, and ALB was significantly lower than that of the healthy control group, the differences were statistically significant(P<0.01). The ESR and DKK1 of the death group were significantly higher than those of the survival group, while ALB was significantly lower than that of the survival group, the differences were statistically significant(P<0.01). The ROC curves showed that the diagnostic value of ESR, ALB, and DKK1 combined detection for MM and the predictive value for the prognosis of MM patients were higher than the detection of any single indicator. Conclusion ESR and DKK1 are up-regulation in MM, while ALB is down-regulation in MM. The combined detection of ESR, ALB, and DKK1 has good diagnostic performance for MM and is worthy of clinical promotion and application as an auxiliary reference index for the occurrence, development, and prognosis judgment of MM.更多还原