【摘要】 目的 探讨以根本原因分析法（RCA）为指导的干预在非小细胞肺癌（NSCLC）化疗患者中的应用效果。方法 根据干预方式的不同将130例NSCLC化疗患者分为观察组（n=72，以RCA为指导的干预）和对照组（n=58，常规干预）。比较两组患者的生活质量[生活质量综合评定问卷（GQOLI-74）]、心理状态[焦虑自评量表（SAS）和抑郁自评量表（SDS）]、睡眠质量[匹兹堡睡眠质量指数（PSQI）]及不良反应发生情况。结果 干预后，两组患者GQOLI-74各维度评分均高于本组干预前，观察组患者GQOLI-74各维度评分均高于对照组，差异均有统计学意义（P﹤0.05）。干预后，两组患者SAS、SDS评分及PSQI各维度评分均低于本组干预前，观察组患者SAS、SDS评分及PSQI各维度评分均低于对照组，差异均有统计学意义（P﹤0.05）。观察组患者不良反应总发生率低于对照组，差异有统计学意义（P﹤0.05）。结论 以RCA为指导的干预可提高NSCLC化疗患者的生活质量和睡眠质量，改善患者的心理状态，降低不良反应发生率。更多还原

【Abstract】 Objective To explore the application effect of root cause analysis(RCA)-guided intervention in nonsmall cell lung cancer(NSCLC) patients undergoing chemotherapy. Method A total of 130 NSCLC patients who underwent chemotherapy were divided into the observation group(n=72, received RCA-guided intervention) and control group(n=58, received routine intervention) according to different intervention methods. The quality of life [generic quality of life inventory-74(GQOLI-74)], psychological status [self-rating anxiety scale(SAS) and self-rating depression scale(SDS)], sleep quality [Pittsburgh sleep quality index(PSQI)], and the incidence of complications were compared between the two groups. Result After intervention, the dimensional scores of GQOLI-74 in the two groups were higer than those before intervention, with higher scores in the observation group than those in the control group(P<0.05). After intervention, the SAS and SDS scores and dimensional scores of PSQI in the two groups were lower than those before intervention, with lower scores in the observation group than those in the control group(P<0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05). Conclusion RCA-guided intervention can improve the quality of life, sleep quality, psychological status of NSCLC patients undergoing chemotherapy, and reduce incidence of adverse reactions.更多还原