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胰腺癌患者血清糖类抗原19-9、糖类抗原242水平及临床意义
Serum carbohydrate antigen 19-9 and carbohydrate antigen 242 levels in patients with pancreatic cancer and their clinical significance
【摘要】 目的 探讨胰腺癌患者血清糖类抗原19-9(CA19-9)、糖类抗原242(CA242)水平及临床意义。方法选取110例胰腺癌患者、100例胰腺炎患者和100例健康体检者,检测3组受试者血清CA19-9、CA242水平,比较不同临床特征胰腺癌患者血清CA19-9、CA242水平。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估血清CA19-9、CA242对胰腺癌的诊断价值。结果 胰腺癌患者血清CA19-9、CA242水平均明显高于体检者和胰腺炎患者,胰腺炎患者血清CA19-9、CA242水平均明显高于体检者,差异均有统计学意义(P﹤0.01)。Ⅲ+Ⅳ期、淋巴结转移胰腺癌患者血清CA19-9、CA242水平均明显高于Ⅰ+Ⅱ期、无淋巴结转移的患者,差异均有统计学意义(P﹤0.01)。血清CA19-9、CA242诊断胰腺癌的AUC分别为0.685、0.682。结论 CA19-9、CA242在胰腺癌患者血清中的水平较高,且其水平与胰腺癌患者临床分期和淋巴结转移有关,但二者单独检测对胰腺癌的诊断价值有限。
【Abstract】 Objective To investigate the serum carbohydrate antigen 19-9(CA19-9) and carbohydrate antigen 242(CA242) levels in patients with pancreatic cancer and their clinical significance. Method A total of 110 patients with pancreatic cancer, 100 patients with pancreatitis and 100 healthy subjects were selected. The levels of serum CA19-9 and CA242 in three groups were detected and compared in pancreatic cancer patients with different clinical characteristics.The receiver operating characteristic(ROC) curve was plotted and the area under the curve(AUC) was calculated to evaluate the diagnostic value of serum CA19-9 and CA242 for pancreatic cancer. Result The levels of serum CA19-9 and CA242 in pancreatic cancer patients were significantly higher than those in pancreatitis patients and healthy subjects(P<0.01), and the levels of serum CA19-9 and CA242 in pancreatitis patients were higher than those in healthy subjects(P<0.01). The levels of serum CA19-9 and CA242 in patients with stage III+IV pancreatic cancer and lymph node metastasis were significantly higher than those with stage I+II pancreatic cancer and without lymph node metastasis(P<0.01). The AUC of serum CA19-9 and CA242 in diagnosis of pancreatic cancer was 0.685 and 0.682, respectively. Conclusion The levels of serum CA19-9 and CA242 are higher in patients with pancreatic cancer, which are associated with clinical stage of pancreatic cancer and lymph node metastasis. However, there is limited value for single detection of CA19-9 and CA242 in the diagnosis of pancreatic cancer.
【Key words】 pancreatic cancer; carbohydrate antigen 19-9; carbohydrate antigen 242; diagnostic value;
- 【文献出处】 癌症进展 ,Oncology Progress , 编辑部邮箱 ,2023年20期
- 【分类号】R735.9
- 【下载频次】9