【摘要】 目的 探讨复方苦参注射液联合化疗治疗中晚期食管癌患者的临床疗效。方法 根据治疗方式的不同将98例中晚期食管癌患者分为对照组（n=48）和观察组（n=50），对照组患者采取常规化疗，观察组患者采取复方苦参注射液联合化疗，两组患者均予以阶段式行为干预。比较两组患者的临床疗效、血清肿瘤标志物[癌胚抗原（CEA）、糖类抗原125(CA125）、糖类抗原19-9(CA19-9）]水平、免疫功能指标（CD3~+、CD4~+、CD8~+水平及CD4~+/CD8~+）及不良反应发生情况。结果 观察组患者的总有效率为72.00%，高于对照组患者的52.08%，差异有统计学意义（P﹤0.05）。治疗后，两组患者的血清CEA、CA125、CA19-9水平均低于本组治疗前，且观察组患者的血清CEA、CA125、CA19-9水平均低于对照组，差异均有统计学意义（P﹤0.05）。治疗后，两组患者CD3~+、CD4~+水平及CD4~+/CD8~+均高于本组治疗前，CD8~+水平均低于本组治疗前，观察组患者CD3~+、CD4~+水平及CD4~+/CD8~+均高于对照组，CD8~+水平低于对照组，差异均有统计学意义（P﹤0.05）。观察组患者的不良反应总发生率为20.00%，明显低于对照组患者的52.08%，差异有统计学意义（P﹤0.01）。结论 复方苦参注射液联合化疗治疗中晚期食管癌能够提高临床疗效，改善患者的免疫功能，降低肿瘤标志物水平及不良反应发生率。更多还原

【Abstract】 Objective To investigate the clinical efficacy of compound sophora flavescens injection combined with chemotherapy in the treatment of patients with advanced esophageal cancer.Method A total of 98 patients with advanced esophageal cancer were divided into control group (n=48) and observation group (n=50) according to different treatment methods.The patients in the control group were treated with conventional chemotherapy,the patients in the observation group were treated with compound sophora flavescens injection combined with chemotherapy,and both groups were given staged behavioral intervention.The clinical efficacy,serum tumor markers[carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125),carbohydrate antigen 19-9 (CA19-9)]levels,immune function indexes (CD3~+,CD4~+,CD8~+levels,and CD4~+/CD8~+) and the occurrence of adverse reaction were compared between the two groups.Result The total effective rate of the observation group was 72.00%,higher than 52.08%of the control group,and the difference was statistically significant (P<0.05).After treatment,the serum levels of CEA,CA125,and CA19-9 in the two groups were lower than those before treatment,and the serum levels of CEA,CA125,and CA19-9 in the observation group were lower than those in the control group,and the differences were statistically significant (P<0.05).After treatment,the levels of CD3~+,CD4~+,and CD4~+/CD8~+in the two groups were higher than those before treatment,and the levels of CD8~+were lower than those before treatment,the levels of CD3~+,CD4~+,and CD4~+/CD8~+in the observation group were higher than those in the control group,and the level of CD8~+was lower than that in the control group,and the differences were statistically significant (P<0.05).The total incidence of adverse reactions in the observation group was 20.00%,lower than 52.08%in the control group,and the difference was statistically significant (P<0.01).Conclusion Compound sophora flavescens injection combined with chemotherapy in the treatment of advanced esophageal cancer could improve the clinical effect and immune function,down-regulate the tumor markers levels,and reduce the incidence of adverse reaction.更多还原