【摘要】 目的：探究益气补虚通络方治疗老年急性冠脉综合征（ACS）经皮冠状动脉介入术（PCI）术后患者的效果及其对血管内皮功能、S100A12蛋白及炎症因子水平的影响。方法：选取许昌北海医院2019年7月—2021年8月103例接受PCI术的ACS患者为研究对象，抽签法分成对照组（51例）和观察组（52例），其中对照组接受常规西医治疗，观察组加服络虚风动理论指导下的自拟益气补虚通络方，连续治疗2个月后比较2组临床疗效，心功能、血管内皮功能、炎症因子水平，以及药物安全性。结果：观察组左心室舒张末期内径（LVDD）、左心室收缩末期内径（LVSD）低于对照组，左室射血分数（LVEF）、舒张早期二尖瓣血流速度峰值与舒张晚期二尖瓣血流速度峰值比值（E/A）高于对照组；观察组内皮素-1(ET-1)、血管性假血友病因子（vWF）、水溶性凝聚素样氧化低密度脂蛋白受体-1(sLOX-1)水平低于对照组，一氧化氮（NO）水平高于对照组；观察组超敏C反应蛋白（hs-CRP）、白细胞介素-6(IL-6)、脑尿钠肽（BNP）、S100A12蛋白（S100A12）水平低于对照组，血管生成素样蛋白4(Angptl4)水平高于对照组，差异均有统计学意义。2组腹泻、恶心、消化不良等不良反应发生率比较无明显差异。结论：在常规西医治疗基础上辅以益气补虚通络方治疗ACS行PCI术后患者效果确切，能够有效改善患者心功能、血管内皮功能、炎症因子水平，安全有效，值得临床推广使用。更多还原

【Abstract】 Objective: To investigate the effect of Yiqi Buxu Tongluo decoction in treating elderly patients with acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI) and its effect on vascular endothelial function, S100A12 protein and inflammatory factor levels. Methods: A total of 103 ACS patients who underwent PCI in Xuchang Beihai Hospital from July 2019 to August 2021 were selected as the research objects. They were divided into a control group(51 cases) and an observation group(52 cases) by lottery. The control group received conventional western medicine. For treatment, the observation group was given the self-made Yiqi Buxu Tongluo Decoction under the guidance of collateral deficiency and wind movement theory. After 2 months of continuous treatment, the clinical efficacy, heart function, vascular endothelial function, inflammatory factor levels, and drug safety were compared between the two groups. sex. Results: The left ventricular end-diastolic diameter(LVDD) and left ventricular end-systolic diameter(LVSD) of the observation group were lower than those of the control group. The peak blood flow velocity ratio(E/A) was higher than that in the control group; endothelin-1(ET-1), von Willebrand factor(v WF), water-soluble clusterinlike oxidized low-density lipoprotein receptor in the observation group The level of-1(s LOX-1) was lower than that of the control group, and the level of nitric oxide(NO) was higher than that of the control group; hypersensitive C-reactive protein(hs-CRP), interleukin-6(IL-6), brain The levels of natriuretic peptide(BNP) and S100A12 protein(S100A12) were lower than those in the control group, and the levels of angiopoietin-like protein 4(Angptl4) were higher than those in the control group, and the differences were statistically significant. There was no significant difference in the incidence of adverse reactions such as diarrhea, nausea, and dyspepsia between the two groups. Conclusion: On the basis of conventional western medicine treatment, Yiqi Buxu Tongluo decoction is effective in treating patients with ACS after PCI. It can effectively improve cardiac function, vascular endothelial function and inflammatory factor levels. It is safe and effective, and it is worthy of clinical promotion.更多还原