【摘要】 目的 观察肺孤立性结节样腺癌PET/CT表现与丙酮酸激酶M2（PKM2）、硒结合蛋白-1（SBP-1）表达的相关性。方法 以101例肺孤立性结节样腺癌为观察组，以68例肺良性肿瘤为对照组；比较2组病灶PKM2、SBP-1表达及PET/CT最大标准摄取值(SUV_max)、峰值标准摄取值(SUV_peak)和肿瘤代谢体积（MTV）,分析观察组病灶PET/CT表现与PKM2、SBP-1表达的关系。结果 观察组病灶PKM2高表达率高于（P<0.001）、SBP-1高表达率低于对照组（P<0.001）;观察组病灶SUV_max、SUV_peak及MTV均高于对照组（P均<0.05）。观察组内PKM2高表达结节呈分叶状、多边形/不规则形、胸膜凹陷征占比及其SUV_max、SUV_peak和MTV均高于PKM2低表达结节（P均<0.05）;SBP-1高表达结节呈分叶状、胸膜凹陷征占比及其SUV_max、SUV_peak和MTV均低于SBP-1低表达结节（P均<0.05）。观察组病灶呈分叶状、出现胸膜凹陷征、SUV_max、SUV_peak及MTV均与其PKM2表达呈正相关、与SBP-1表达呈负相关（P均<0.05）。结论 肺孤立性结节样腺癌PET/CT表现与其PKM2及SBP-1表达相关。更多还原

【Abstract】 Objective To observe the correlations of PET/CT findings,expression of pyruvate kinase M2 （PKM2）and selenium binding protein 1（SBP-1）of pulmonary solitary nodular adenocarcinoma.Methods A total of 101 patients with pulmonary solitary nodular adenocarcinoma（study group）and 68 patients with benign lung tumors（control group）were enrolled.The expression of PKM2and SBP-1,the maximum standard uptake value(SUV_max),peak standard uptake value(SUV_peak)and metabolic tumor volume（MTV）of lesions were compared between groups.The correlations of PET/CT manifestations,the expression of PKM2 and SBP-1 of lesions in study group were analyzed.Results High expression rate of PKM2 of lesions in study group was higher（P<0.001）,while of SBP-1 was lower than those in control group（P<0.001）.SUV_max,SUV_peakand MTV of lesions in study group were all higher than those in control group（all P<0.05）.In study group,the percentage of lobar sign,polygonal/irregular shape and pleural depression sign,as well as SUV_max,SUV_peakand MTV of nodules with high PKM2 expression were higher than those of nodules with low PKM2expression（all P<0.05）,while the percentage of lobar sign and pleural depression sign,as well as SUV_max,SUV_peakand MTV of nodules with high SBP-1 expression were lower than those of nodules with low SBP-1 expression（all P<0.05）.The lobar sign,pleural depression sign,SUV_max,SUV_peakand MTV of lesions in study group were positively correlated with PKM2expression but negatively correlated with SBP-1 expression （all P<0.05）.Conclusion PET/CT findings of pulmonary solitary nodular adenocarcinoma were correlated with the expression of PKM2and SBP-1.更多还原